FXIa Inhibitor Milvexian Fails Pivotal Test

Because FXI deficiency is associated with mild variable bleeding, researchers have been developing a direct anticoagulant specific to FXIa, intending to provide effective anticoagulation while reducing the bleeding risk that plagues other antithrombotics. Here is a FirstWord Pharma post in which Bristol-Myers Squibb and Johnson & Johnson report an interim finding in their Librexia ACS (acute coronary syndrome) Milvexian® study that shows inadequate efficacy. Meanwhile, the trial continues to look for stroke prevention in non-valvular atrial fibrillation.