Anticoagulant Therapy

Omaha Presentation Handouts

George substituted for Dave McGlasson and presented, “Monitoring the New Antithrombotics: Whatever Happened to the PT and PTT?” on Wednesday, April 3, 10 AM; and “Antiplatelet Therapy, Do Aspirin and Plavix Work?” on Thursday, April 3, 2:30–2:30 PM at the Great Plains Regional Laboratory Expo in Omaha Nebraska. His presentation handouts, in PDF, appear on our Audio Modules page. Thanks […]

Anticoagulant Therapy

Does Apixaban Affect Clot-based Assays?

From Linda Stang, Alberta Health Services: As apixaban (Eliquis) is sure to start wreaking havoc in some of our special coag assays (read: tests will be ordered while patients are on this drug, but they WON’T tell us…), I did a search for publications about apixaban interference, and found nothing. Does anyone have any experience with interference […]

Anticoagulant Therapy

New Rivaroxaban Indication in Europe

On Friday, March 22 the European Medicines Agency Committee for Medicinal Products for Human Use cleared rivaroxaban (Xarelto) for prevention of atherothrombotic events in patients with acute coronary syndrome. EMA made this decision a few weeks after the US FDA disapproved the drug for the same indication. The news release appears on TheHeart.org.

Anticoagulant Therapy

Still More on Dabigatran Risks

Here is a summary of the FDA’s adverse events report suggesting a higher case fatality rate than in the Mini-Sentinel report published in the March 13, 2013 New England Journal of Medicine. The argument continues.

Anticoagulant Therapy

ACT Testing Time Interval

Here is a question from my friend and colleague Kathleen Finnegan, MS MT (ASCP )SH, Chair of the CLS program at Stony Brook University, New York. This question was posted to the ASCLS Consumer Web Forum through Lab Tests Online: “In the procedure room setting (cardiac catheterization or EP lab) what is the standard length of time to wait to […]

Anticoagulant Therapy

Dabigatran Bleeding Rate

The March 13, 2013 New England Journal of Medicine released a perspective, Dabigatran and Postmarketing Reports of Bleeding. The authors contend that early reports citing a bleeding rate higher than Coumadin may have been a symptom of intense market vigilance with over-reporting of events. Geo.

Anticoagulant Therapy

Dabigatran May Shorten Hospital Stay

The Heart.org posted a small but powerful study today illustrating that dabigatran (Pradaxa) may shorten the inpatient stay because it eliminates the need for coverage by heparin or fondaparinux and eliminates the need to tinker with dosage to hit the target international normalized ratio (INR). Yet more good new for dabigatran. Geo.

Anticoagulant Therapy

No More PT in Seconds?

From Dr. Larry Brace, Edward Hospital, Naperville, IL: I need an opinion. Here is my view on prothrombin time (PT) in seconds. We should no longer have to do a normal range for the PT in seconds. We know that the general consensus is that the international normalized ratio (INR) is considered normal to at least 1.2 […]

Anticoagulant Therapy

Triple Antithrombotic Therapy

Prof. Bernadette Rodak of Indiana University forwarded a question about parallel anticoagulant and antiplatelet therapy from the ASCLS Consumer Web Forum. In the interest of confidentiality, I paraphrase the question: “What should the international normalized ratio (INR) be when on simultaneous antiplatelet therapy (aspirin and clopidogrel) for percutaneous intervention (PCI) stent placement and anticoagulation therapy (Coumadin) […]

Anticoagulant Therapy

Rapid INR Rise in Pneumonia

From Michael Huang, MicroPoint Bio: An 80 yr old male on warfarin was admitted to A&E of a local hospital for the complaint of shortness of breath. Lab test results showed INR of 15 after his admission. Just 8 hours before, the POC instrument his doctor used to monitor his INR showed a reading of 2.6. The […]

Anticoagulant Therapy

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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