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Factor Inhibitors: The SIPPET Study

Here is a short free full text article describing the outcomes of the 2010–17 Survey of Inhibitors in Plasma-Product Exposed Toddlers (SIPPET) study. The study compares inhibitor incidence arising from rFVIII (recombinant) concentrate compared to pdFVIII (plasma-derived) concentrate. Further, in an important addition to hemophilia therapy protocol, SIPPET also compares inhibitor incidence in hemophilic F8 […]

Bleeding Disorders

Hemostasis Curriculum

For those of us who have teaching responsibilities, here is a JTH pre-pub that provides a comprehensive list of hemostasis topics: Moffat KA, Kiencke V, Blanco AN, McLintock C, Peyvandi F, et al., International Society on Thrombosis and Haemostasis core curriculum project: core competencies in laboratory thrombosis and hemostasis. J Thromb Haemost. 2019. doi: 10.1111/jth.14601. […]

Graduate Courses

George leads Michigan State University’s graduate online hemostasis course, BLD 835: Hemostasis, Thrombosis, and Resource Management beginning August 28, 2019. Please contact MSU’s Biomedical Laboratory Science program for enrollment and registration information. In addition, George will participate in Rutgers University’s online Advanced Hemostasis course led by Dr. Catherine Otto, Rutgers School of Health Professions. Contact […]

July 2019 CAP DOACs Article

The July, 2019 issue of CAP Today offers an article describing hemostasis testing for patients on DOACs by Dr. Dorothy M. Adcock, Chief Medical Officer and Senior Vice President, LabCorp. Tap or click here for “What is the Impact of Direct Oral Anticoagulants?”

Anticoagulant Therapy

August, 2019 Cheat Sheet

Tap or Click here for our August Cheat Sheet. If you are a Cheat Sheet subscriber, this month’s sheet will arrive in your mailbox later this week.

July, 2019 QQ: Managing Trauma

Our July, 2019 Quick Question was directed to trauma centers, and attracted 22 responses. The question was… How does your institution manage trauma-induced coagulopathy? Crystalloid plasma expanders 3 (14%) pRBCs 2 (9%) 1:1:1 components 12 (54%) Whole blood 2 (9%) Tranexamic acid 3 (14%) Thank you for your answers. Arising from military experience, a handful […]

Bleeding Disorders

More on D-dimer Elevated 6 Months

Here is a follow-up on yesterday’s (July 23, 2019) case study describing chronically elevated D-dimer. Our correspondent has graciously offered her permission to post her message (anonymously, of course). Another question for you. If there were a blood clot in my lungs would the CT chest scan be a definitive factor for ruling it out? […]

More on Venous Thoracic Outlet Syndrome

George draws your attention to our June 27, 2019 entry describing venous thoracic outlet syndrome afflicting an athletic friend. Our frequent contributor and hemostasis scholar Dr. Vadim Kostousov today, July 24, 2019, provided a seriss of references to VTOS in unusual circumstances.

D-dimer Elevated 6 Months

Dear George, I am a 42 year old African American women in fairly good health. I am obese and I live a partly active life. I went to the emergency room back in January of this year for chest pain and palpitations. While there they did a D-dimer test and a chest CT scan. I […]

Therapeutic Reptilase

Ning Tang writes, Dear George, In China, a categary of hemostatic agents from snake venom named “Haemocoagulase” are widely used, basically they are the generic drugs of Reptilase®, which is produced by a Swiss company. We find that intravenous injection of this drug can cause severe hyperfibrinolysis and hypofibrinogenemia. It seems that Reptilase has been […]

Bleeding Disorders

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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