Normalized Activated Protein C Sensitivity Ratio Predicts VTE in OCR

Here is an open-access report on a noteworthy primary research piece detailing an assay that predicts VTE risk associated with oral contraceptives: Morimont L, Creinin MD, Gaspard U, Foidart JM, and Douxfils J. Predicting venous thromboembolism risk from an endogenous thrombin potential-based normalized activated protein C sensitivity ratio assay: toward early assessment of combined oral […]

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Thrombophilia

Feb 7 2026

george

ADAMTS-13 Conformation

What if we’ve been monitoring the wrong biomarker in iTTP remission? In immune-mediated TTP, we obsess over ADAMTS13 activity to predict relapse. But what if activity isn’t the earliest warning sign? A fascinating new study suggests the real signal may be hiding in ADAMTS13 conformation. Here is the open-access link: Joly BS, Roose E, Dekimpe […]

Thrombophilia

Review: VWD Type 2A

From Emmanuel Favaloro, PhD, Editor-in-Chief, Seminars in Thrombosis and Hemostasis: 2026 marks the 100th anniversary of the initial publication of a bleeding disorder, “pseudo-hemophilia’ that was later to become known as von Willebrand disease. Seminars in Thrombosis and Hemostasis will publish several papers on VWD in 2026. This is the first one in the queue–on […]

Bleeding Disorders

Review: Hemostasis Biomarkers

Here is a January 2026 comprehensive review of commonly used and esoteric hemostasis disorder biomarkers in downloadable format: Reardon B, Pasalic L, Favaloro EJ. Biomarkers of coagulation disorders—where to from here? Biomolecules 2026: 16, 235. https://doi.org/10.3390/biom16020235. Abstract Disorders of thrombosis and bleeding contribute to a significant morbidity and mortality burden worldwide. Correctly identifying contributing factors […]

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Global Hemostasis Assays

Feb 4 2026

george

Review: Clot Waveform Analysis

Click this open-access article that reviews attempts at harmonization of clot waveform analysis: Tan JY, De Guzman MRT, Wong WH, et al. Decoding clot waveform analysis: toward better understanding and harmonization. Semin Thromb Hemost. 2026. doi: 10.1055/a-2778-9810. PMID: 41506647. Abstract Clot waveform analysis (CWA) extends routine coagulation assays (activated partial thromboplastin time [PTT] and prothrombin […]

Screening Assays

Thrombophilia Testing After Provoked DVT

Following 2023 ASH guidelines, should facilities proceed with thrombophilia screening for patients who develop VTE following transient triggers? Here is an open-access essay on the effects of the ASH guidelines that appears in the January 1, 2026, issue of Clinical Laboratory News, an ADLM publication. Click “Does Provoked VTE Warrant Thrombophilia Testing?“

Thrombophilia

What is the MRX PT DOAC Assay?

Thanks to Ali Sadeghi-Khomami, PhD, Precision BioLogic Inc., for a heads-up describing the MRX PT DOAC assay, offered by Nordic Biomarker, Umeå and Linköping, Sweden. For details about the assay, obtain this article from your medical library: Salter B, Moffat K, Carlino S, et al. Evaluation of the MRX PT DOAC assay for detection of clinically […]

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Anticoagulant Therapy

Jan 30 2026

george

Review: Neutrophil Extracellular Traps (NETs) in Thrombosis

This open-access review scans literature associating NETs with coagulation: Huang G, Wu H, Lin B, et al. Targeting neutrophil extracellular traps: a new strategy for the treatment of acute ischemic stroke based on thrombolysis resistance. Semin Thromb Hemost. 2026;52:80-91. doi: 10.1055/a-2609-3457. PMID: 40461018; PMCID: PMC12799313. Abstract Acute ischemic stroke (AIS) is a life-threatening thrombotic disorder, […]

Arterial Thrombosis

January 2026 Cheat Sheet

Click here to read our January 2026 Cheat Sheet. The Cheat Sheet introduces and reviews our Quick Questions and presents current developments in hemostasis. If you would like a personal version of the Cheat Sheet featuring links to our January posts, please complete the form on the right. Precision BioLogic Inc. provides free access to […]

Cheat Sheets

February 2026 QQ: DOACs

Our February 2026 Quick Question is a quiz that asks, “Which DOAC is a direct thrombin inhibitor?” Since 2010, DOACs have become our primary antithrombotic agents prescribed for prophylaxis or therapy. While more DOACs are on the horizon, the current anticoagulants directly inhibit either thrombin or FXa. Please make your selection in the right-hand column […]

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Quick Question Archive

All Posts

Normalized Activated Protein C Sensitivity Ratio Predicts VTE in OCR

ADAMTS-13 Conformation

Review: VWD Type 2A

Review: Hemostasis Biomarkers

Review: Clot Waveform Analysis

Thrombophilia Testing After Provoked DVT

What is the MRX PT DOAC Assay?

Review: Neutrophil Extracellular Traps (NETs) in Thrombosis

January 2026 Cheat Sheet

February 2026 QQ: DOACs

George Fritsma MS MLS

Cheat Sheets from George

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