Click Rahman M, Black KM, Sadeghi-Khomami A; An Automated Lupus Anticoagulant Assay Resistant to Anticoagulant Drugs Including DOACs and Oral FXI Inhibitors for a 2016 ISTH poster that documents an updated LAC assay.
Background
Direct oral anticoagulants (DOACs) and oral FXI inhibitors interfere with LAC testing by prolonging clotting times and increasing assay variability. Activated charcoal (Act-C) adsorbs hydrophobic anticoagulants but typically requires plasma sample pretreatment. Although the cryocheck™ Hex LA™ assay is resistant to heparin, vitamin K antagonists (VKAs), and factor deficiencies while remaining diagnostically accurate in the presence of DOACs and oral FXI inhibitors, 3-4 Act-C integration could further reduce anticoagulant-related clotting-time prolongation and delta value increase.
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