August, 2021 Quick Question: Factor Deficiency

Our August 2021 Quick Question, which asks, “Which factor deficiency causes the smallest risk of bleeding?” drew a respectable 48 votes. Answers: VWF deficiency: 9% [4] Factor X deficiency: 4% [2] Factor XI deficiency: 7% [3] Factor XII deficiency: 52% [24] Prekallikrein deficiency: 28% [13] Both 4 and 5 are correct, deficiencies of contact factors […]

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Bleeding Disorders

Aug 31 2021

george

Webinar: Rare Thrombotic Response to a SARS-CoV-2 Vaccine

Please join us for a compelling discussion about the rare, unusual thrombotic events that develop in association with thrombocytopenia approximately one to two weeks after vaccination with a SARS-CoV-2 vaccine. This incidence of thrombocytopenia is mediated by platelet-activating antibodies against platelet-factor 4, without any exposure to heparin, and it mimics heparin-induced thrombocytopenia. Don’t miss this […]

Events

Factor V Inhibitor

I [Geo] am preparing an audio PowerPoint module describing the primary coagulation assays, PT, PTT, TT, and fibrinogen [Fg] assays. I asked several colleagues if we continue to encounter factor V inhibitors. Before ~2010 we encountered anti-FV and sometimes anti-FV plus anti-FII [prothrombin] as cross-reacting antibodies that arose in response to bovine thrombin used in […]

Screening Assays

Chromogenic Vs. Clot-based FVIII Assays

The Precision BioLogic Inc. and the Affinity Biologicals, Inc. research team presented a poster comparing chromogenic versus clot-based factor VIII assays measuring pegylated factor VIII therapeutic concentrate at the July 17–21, 2021 meeting of the International Society on Thrombosis and Haemostasis. The poster is now available for your download: Tara Quinton, John Fraser, Karen M. […]

Bleeding Disorders

Factor VIII Antigen in Factor VIII Inactivated Plasma

At the July 17–21, 2021 meeting of the International Society on Thrombosis and Haemostasis, the Precision BioLogic Inc. and the Affinity Biologicals, Inc. research team presented a poster that demonstrates how inactivated factor VIII reagent preparations that are employed for factor VIII activity assays and inhibitor assays may contain factor VIII that is detectable by […]

Bleeding Disorders

Factor VIII Antigen Enzyme Immunoassay

The Precision BioLogic Inc. and the Affinity Biologicals, Inc. research team presented a poster describing their factor VIII antigen immunoassay recovery of various therapeutic concentrates at the July 17–21, 2021 meeting of the International Society on Thrombosis and Haemostasis. The poster is now available for your download: Ni R, Erb P, DellaMaestra, J, Atkinson H,Foulon […]

Bleeding Disorders

Thrombosis in VWF and Hemophilia

From Crystal Wilson: Hello George, I am writing to ask if you could help me to understand how, on rare occasions, patients suffering from bleeding disorders such as von Willebrand disease or hemophilia have suffered from hypercoagulable episodes such as pulmonary emboli or deep vein thrombosis. Thanks. Hello, Crystal, I sent your question to several […]

Bleeding Disorders

Chromogenic Factor IX Assay

The Precision BioLogic Inc. and the Affinity Biologicals, Inc. research team presented a poster describing the recovery characteristics of a new chromogenic factor IX assay at the July 17–21, 2021 meeting of the International Society on Thrombosis and Haemostasis. The poster is now available for your download: Tara Quinton, Rachel Clarke, John Fraser, Karen M. […]

Bleeding Disorders

August, 2021 Quick Question

Our August, 2021 Quick Question is “Which factor deficiency causes the smallest risk of bleeding?” Please answer at your convenience. This question may lead us to a discussion of the current research developments for safer anticoagulant preparations.

Bleeding Disorders

July, 2021 Quick Question: Covid Inflammatory Cell Results

Our July, 2021 Quick Question was, “Which cell is the main cause of thrombo-inflammation in a COVID-19 infection?” We had 43 respondents to our selections: Endothelial cell: 35% [15] Platelet: 44% [19] Monocyte-macrophage: 12% [5] polymorphonuclear neutrophil: 9% [4] There’s no right answer, as all of these cells are involved in inflammation, however, many who […]

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Quick Question Archive

All Posts

August, 2021 Quick Question: Factor Deficiency

Webinar: Rare Thrombotic Response to a SARS-CoV-2 Vaccine

Factor V Inhibitor

Chromogenic Vs. Clot-based FVIII Assays

Factor VIII Antigen in Factor VIII Inactivated Plasma

Factor VIII Antigen Enzyme Immunoassay

Thrombosis in VWF and Hemophilia

Chromogenic Factor IX Assay

August, 2021 Quick Question

July, 2021 Quick Question: Covid Inflammatory Cell Results

George Fritsma MS MLS

Cheat Sheets from George

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