CAP Today: Specimen Collection

Here are two CAP Today front-page articles featuring Dorothy Adcock, MD and Richard Marlar, PhD regarding coagulation specimen collection: September 2021: In Coag Collections, Every Detail Counts February 2022: Steps to Preventing Coag Test Processing Error These are richly referenced articles that draw attention to International Council for Standardization in Haematology guidelines.

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Specimen Management

Feb 18 2022

george

Measuring DOACs

Here is a helpful article from the January 17, 2022 issue of CAP Today: “Measuring Direct Oral Anticoagulants—When, How.”

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Anticoagulant Therapy

Feb 18 2022

george

PIVKA

George is updating a book chapter and asks if there is a reason to continue using the phrase “proteins induced by vitamin K absence/antagonists” [PIVKA], now termed des-gamma-carboxy- II, VII, IX, or X. Does any laboratory continue to offer a PIVKA assay?

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Anticoagulant Therapy

Feb 18 2022

george

FDP and D-dimer

A question for discussion. Is there any clinical reason to test for both fibrin degradation products [FDPs] and D-dimer?

Fibrinolysis

COVID-19: VWF/ADAMTS13 Balance

Thanks to Brandon Michael Henry MD, Cincinnati Children’s Hospital Medical Center for drawing attention to his award-winning review, co-authored with Drs. Emmanuel Favaloro and Giuseppe Lippi, which details the relationship between von Willebrand factor and ADAMTS13 and applies the VWF/ADAMTS13 activity ratio to the thrombotic progression of the SARS-CoV2 infection. The authors review 67 primary […]

Arterial Thrombosis

February 2022 Cheat Sheet

Our February 2022 Cheat Sheet is attached. Please contact George at [email protected] if you’d like a push copy to arrive in your mailbox.

Cheat Sheets

February, 2022 Quick Question: Platelet Aggs

Our February 2022 Quick Question asks, What single agonist is your first choice to measure platelet response to aspirin? The typical aggregation profile includes several agonists, however it may be that one is more sensitive to aspirin’s antiplatelet effect than the others. As always, please add your comments below.

Antiplatelet Therapy

January 2022 Quick Question: Case Study

We had 58 responses to our January 2022 Quick Question. The stem asked, “A patient experiences soft tissue bleeding and poor wound healing. The PT, PTT, and TT are normal. What follow-up profile do you recommend? Factors VIII, IX, & XI assays: 10% [6] PAI-1 & D-dimer assays: 0 Thrombosis risk profile: 2% [1] Platelet […]

Bleeding Disorders

Chromogenic Vs. Clot-based Gene Transfer FVIII Assays

This article in Blood illustrates the disparity between chromogenic and clot-based factor VIII assays when measuring factor VIII activity produced by hemophilic recipients of gene transfer factor VIII: Rosen S, Tiefenbacker S, Robinson M, et al. Activity of transgene-produced B-domain–deleted factor VIII in human plasma following AAV5 gene therapy. Blood 2020;136:2524–34. Thanks to Dean Willett, […]

Bleeding Disorders

Biomarin Factor VIII Gene Transfer Results

Click here to see Biomarin’s 1-9-22 announcement of their 134-participant factor VIII gene transfer trial, valoctocogene roxaparvovec. Thanks to Dean Willett, Precision BioLogic Inc. for alerting us to this encouraging development.

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Bleeding Disorders

All Posts

CAP Today: Specimen Collection

Measuring DOACs

PIVKA

FDP and D-dimer

COVID-19: VWF/ADAMTS13 Balance

February 2022 Cheat Sheet

February, 2022 Quick Question: Platelet Aggs

January 2022 Quick Question: Case Study

Chromogenic Vs. Clot-based Gene Transfer FVIII Assays

Biomarin Factor VIII Gene Transfer Results

George Fritsma MS MLS

Cheat Sheets from George

Questions or Comments?

Quick Question