Estrogen and Progesterone

Here is a question from my (Geo) friend and colleague, Kathryn Doig, MLS, PhD: “We all know that some women are prone to clots with both birth control hormones and menopausal hormones, but I want to understand why. I found a good review article with a reference (I have since lost) that showed an increase […]

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Thrombophilia

Sep 25 2025

george

Incubation to Inactivate Efanesoctocog Alfa Prior to Inhibitor Bethesda Titer

Click here for an open-access letter that indicates the need to inactivate plasma EHL FVIII efanesoctocog alfa (Altuuviiio®; Altuvoct®) before performing a Bethesda titer to measure anti-FVIII inhibitor: Bowyer A. Is incubation for 30 minutes at 56°C sufficient to fully inactivate efanesoctocog alfa? Haemophilia. 2025. doi: 10.1111/hae.70137. PMID: 40985057. The findings provide a recommended incubation […]

Bleeding Disorders

Does Chewing Gum Affect Fasting Blood Specimens?

On September 23, 2025, friend and colleague Dave McGlasson had a fasting blood specimen drawn. The collector noted that he was chewing gum and explained that the gum, although sugar-free, could affect the results. McGlasson messaged, “Chewing sugar-free gum should be avoided before a fasting blood draw because it can elevate certain blood levels, including […]

Specimen Management

WFH Fibrinogen Disorders Booklet

Click here for a recent WFH booklet, What Are Fibrinogen Disorders?

Bleeding Disorders

Reprise: In Vitro DOAC Removal

At the request of the Annals of Blood editor, here is a link to our 2020 article on in vitro DOAC removal agents, which has attracted >5000 page views: McGlasson DL Fritsma GA. In vitro detection and removal of direct oral anticoagulants from patient plasma specimens. Ann Blood 2020;5:25 | http://dx.doi.org/10.21037/aob-20-16. The article was first […]

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Anticoagulant Therapy

Sep 22 2025

george

Elevated PT/INR Case

This question recently appeared in the Diagnostic Health Equity site, managed by Tamara Lobban-Jones. “My doctor said my PT/INR was a little high. What does that actually mean for me, and should I be worried about bleeding more easily? I’ve been on a blood thinner for a while, but my PTT keeps coming back different […]

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Anticoagulant Therapy

Sep 19 2025

george

AI and Platelet Counts

Go to your medical library to see this 2025 article, Guy J, Béné MC, Simon Lopez R, Maynadié M, Row C. Exploring the performance of an artificial intelligence- and morphology-driven workflow integrating 4 platelet enumeration technologies. Am J Clin Pathol. 2025;164:385–9. doi: 10.1093/ajcp/aqaf055. PMID: 40493735. Abstract Objective Platelet count, one of the main parameters of the […]

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Platelet Function Testing

Sep 19 2025

george

A Relationship Between Radiotherapy and Venous Thrombosis

Click here for an open-access 2025 article that describes the relationship between radiotherapy and cancer-associated venous thrombosis: Gurumurthy G, Miller J, Carrier M, Khorana A, Thachil J. Radiotherapy-the not-so-insignificant contributor to cancer-associated venous thrombosis. Res Pract Thromb Haemost. 2025;9:102985. doi: 10.1016/j.rpth.2025.102985. PMID: 40837025; PMCID: PMC12362088. Abstract Venous thromboembolism is a well-established complication in patients with […]

Thrombophilia

Effect of Rebalancing Therapy on Coagulation Assays

Click to read this open-access article that explores the effects of antithrombin reduction (rebalancing) hemophilia therapy on a series of coagulation tests: Chhabra, ES ; Liu, M. Evaluation of the interference of fitusiran and antithrombin lowering in plasma on routine coagulation assays. Research and practice in thrombosis and haemostasis, 2025;9:102989–9.

Bleeding Disorders

A Review of Current and Developing DOAC Reversal Agents

Check with your medical library for this comprehensive review of current and developing DOAC reversal agents: Gómez-Outes A, Suárez-Gea ML, Lecumberri R. When and how to use reversal agents for direct oral anticoagulants? Curr Cardiol Rep. 2023;25:371–80. doi: 10.1007/s11886-023-01858-x. PMID: 36976497. Abstract Purpose of review: Our objective is to describe currently available reversal agents for […]

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Anticoagulant Therapy

All Posts

Estrogen and Progesterone

Incubation to Inactivate Efanesoctocog Alfa Prior to Inhibitor Bethesda Titer

Does Chewing Gum Affect Fasting Blood Specimens?

WFH Fibrinogen Disorders Booklet

Reprise: In Vitro DOAC Removal

Elevated PT/INR Case

AI and Platelet Counts

A Relationship Between Radiotherapy and Venous Thrombosis

Effect of Rebalancing Therapy on Coagulation Assays

A Review of Current and Developing DOAC Reversal Agents

George Fritsma MS MLS

Cheat Sheets from George

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