More on Clopidogrel Efficacy

This is a February 18, 2014 follow-up from the individual whom I responded to in a January 30 post entitled Clopidogrel Efficacy. I had collaborated with Prof. Bernadette Rodak of Indiana University on the original email to the questioner. Here is the comment (with identification removed): “I would like to thank you and Prof. Rodak for your response […]

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Antiplatelet Therapy

Feb 17 2012

george

More on PTT Specimen Storage Time

On November 1 I replied to a question from Joe Lamb, Columbus, GA about room temperature storage of specimens for partial thromboplastin time (PTT) assays that are sent to reference laboratories. Joe was concerned that his reference lab claimed PTT results were valid on specimens less than 24 hours old, whereas the CLSI Guideline H21-A5 sets […]

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Anticoagulant Therapy

Feb 15 2012

george

Normal Plasma Storage

Here is a seemingly simple request from Vicki Lanigan at Niagara Health, Ontario, Canada: “I am looking for a reference for storage of normal pooled plasma (NPP, pooled normal plasma, PNP).” Vicki, this one drove me back to the books and to the package inserts for distributors Precision BioLogic Inc and George King Bio-Medical, Inc to learn the shelf life for […]

Specimen Management

Ann Bell

This announcement from Prof. Bernadette Rodak of Indiana University has relatively little to do with hemostasis, however I am certain many of our subscribers knew Prof. Ann Bell (I received a similar message today from Dr. Larry Brace of Edward Hospital, Naperville): “Some of our more mature techs will remember Miss Ann Bell of Memphis TN, who worked with Dr Diggs for so many years […]

Events

Serotonin Release by Immunoassay?

Dear George, For heparin-induced thrombocytopenia (HIT) serotonin release assay, can serotonin ELISA sensitive to HIT be used? With regards, Vilas Hiremath. Hello, Vilas, always good to hear from you. I had to go to experts, Drs Larry Brace, Edward Hospital in Naperville IL, and Jon Geske, Precision BioLogic Manager of Emerging Technologies & Markets. Here is a reply […]

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Anticoagulant Therapy

Feb 2 2012

george

Advance: Antiplatelet Drugs

Frequent contributor Dave McGlasson and I assisted with this January 11 Advance for Administrators of the Laboratory Karen Appold article entitled New Antiplatelet Drugs Bring Benefits. You may find the discussion helpful. The article requires one minor edit when reading, the glycoprotein IIb/IIIa inhibitors are described as “injectable,” they are actually administered intravenously. I hope you enjoy the article. Geo.

Antiplatelet Therapy

Inflammatory Markers

Here is another cogent comment from a University of Medicine and Dentistry Graduate Student. I didn’t get permission to post the student’s name, will add it later in a comment if permission is granted. We got into a side “conversation” about inflammatory markers and their crosstalk with hemostasis. As you can see, we get into some […]

Coagulation Factors

PT and PTT for Preoperative Screens

I’m having some fun this week teaching a unit in the online graduate hemostasis course at the University of Medicine and Dentistry of New Jersey at the invitation of Drs Elaine Keohane and Nadine Fydryszewski. This also gives me the opportunity to work with colleagues Donna Castellone and Dr. Larry Smith. Many of our twelve students are seasoned veterans in hematology […]

Screening Assays

PRP Gel, Platelet Substitute

Another interesting discussion from our UMDNJ graduate Hemostasis course: About 6 years back, I caught wind of a discussion regarding platelet substitutes, which I found quite intriguing. I did some digging as a result of this discussion and am amazed by the potential of such technologies. It appears that platelet rich plasma (PRP) gel has been around […]

Bleeding Disorders

Fondaparinux Assay

Hi George! Would you happen to have a list of laboratories performing the anti-Xa assay for Fondaparinux (pentasaccharide, Arixtra)? Do you recommend, when calibrating the assay, to use commercially-available material or spiked normal pooled plasma (NPP)? Thanks for your help!! Love this resource that you provide!! Crystal Azevedo, MT(ASCP)SH Hi, Crystal, thanks for your comment. Machaon […]

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Anticoagulant Therapy

All Posts

More on Clopidogrel Efficacy

More on PTT Specimen Storage Time

Normal Plasma Storage

Ann Bell

Serotonin Release by Immunoassay?

Advance: Antiplatelet Drugs

Inflammatory Markers

PT and PTT for Preoperative Screens

PRP Gel, Platelet Substitute

Fondaparinux Assay

George Fritsma MS MLS

Cheat Sheets from George

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