PTT Reagent LA Sensitivity in Mixing Studies

Hello George, My name is Marcelo Gonçalves, clinical pathologist from Hematology Department of Hermes Pardini Laboratory, Brazil. I would like to ask what kind of activated partial thromboplastin time (APTT, PTT) reagents should be used in APTT mixing studies (high or low responsiveness to LA)? Thank you for your attention. Dr. Marcelo Luide Pereira Gonçalves Thank […]

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Lupus Anticoagulant

Sep 12 2012

george

Validating High POC INR Results

Our April 24, 2012 post (and Quick Question), POC: When to Validate a High INR has attracted a provocative comment from Alan Neal of New Zealand. I’ve added this link so the comment does not get buried and to attract additional discussion from our participants.

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Anticoagulant Therapy

Sep 12 2012

george

Validating High POC INR Results

Our April 24, 2012 post (and Quick Question), POC: When to Validate a High INR has attracted a provocative comment from Alan Neal of New Zealand. I’ve added this link so the comment does not get buried and to attract additional discussion from our participants.

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Anticoagulant Therapy

Sep 12 2012

george

Hybrid Curve Controls for Anti-Xa Heparin Assay

This is from frequent contributor Crystal Azevedo, Eastern Maine Healthcare Systems. Hi George, Look forward to seeing you next month in Portland, Maine! I am setting up a hybrid curve for heparin monitoring using the Rotachrom Heparin reagent and Stago’s hybrid calibrator. Which control material should be used with this curve? Thanks! Hi, Crystal, I look forward […]

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Anticoagulant Therapy

Sep 7 2012

george

Preparing PPP

From Rebecca Jones, Trinity Medical Center, Birmingham: Hey George, love the website! If only all disciplines had access to all this knowledge! Thanks for all you do. I have another question for you to ponder…or not. What is your feeling about performing a “hard spin” on coagulation specimens? We do a “quick spin” for 2–3 minutes […]

Specimen Management

Dabigatran Gene Variant

Here’s a new outcome from the Dabigatran etexilate RE-LY study that suggests there is a gene variant in 1/3 of Caucasians that converts less of the prodrug, reducing the risk of bleeding without reducing efficacy.

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Anticoagulant Therapy

Sep 6 2012

george

TRILOGY ACS: Prasugrel Efficacy

Here is a link to a recent TRILOGY ACS report indicating that prasugrel (Effient) is equivalent to clopidogrel (Plavix) in reducing major cardiovascular events.

Antiplatelet Therapy

Conference Calendar Updates

I invite you to have a look at several new conference opportunities scheduled for September–December, 2012 recently posted on our Coag Conference Announcements page.

Events

Prolonged Mixing Study in Dialysis

From “Balasubm” at Einstein Healthcare in Philadelphia: Hi George, I have a 74 year old female renal dialysis patient who is asymptomatic with prolonged prothrombin time (PT) of 38 seconds and activated partial thromboplastin time (APTT, PTT) of 116 seconds, with a normal thrombin time. Mixing performed immediately reveals PT of 30.3 seconds (N 9.5-13.5) and […]

Lupus Anticoagulant

PT & PTT on a Lipemic Specimen

From Janice Stringfield, Jennie Stuart Medical Center, Hopkinsville, KY: We have an extremely lipemic specimen that we have a prothrombin time (PT) and activated partial thromboplastin time (APTT, PTT) ordered on from the ED. How do you get a result? We can’t find anyone that does a mechanical method anymore. Do you have any suggestions? Hi, Janice, […]

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Specimen Management

All Posts

PTT Reagent LA Sensitivity in Mixing Studies

Validating High POC INR Results

Validating High POC INR Results

Hybrid Curve Controls for Anti-Xa Heparin Assay

Preparing PPP

Dabigatran Gene Variant

TRILOGY ACS: Prasugrel Efficacy

Conference Calendar Updates

Prolonged Mixing Study in Dialysis

PT & PTT on a Lipemic Specimen

George Fritsma MS MLS

Cheat Sheets from George

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