What is the MRX PT DOAC Assay?

Thanks to Ali Sadeghi-Khomami, PhD, Precision BioLogic Inc., for a heads-up describing the MRX PT DOAC assay, offered by Nordic Biomarker, Umeå and Linköping, Sweden. For details about the assay, obtain this article from your medical library: Salter B, Moffat K, Carlino S, et al. Evaluation of the MRX PT DOAC assay for detection of clinically […]

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Anticoagulant Therapy

Jan 30 2026

george

Review: Neutrophil Extracellular Traps (NETs) in Thrombosis

This open-access review scans literature associating NETs with coagulation: Huang G, Wu H, Lin B, et al. Targeting neutrophil extracellular traps: a new strategy for the treatment of acute ischemic stroke based on thrombolysis resistance. Semin Thromb Hemost. 2026;52:80-91. doi: 10.1055/a-2609-3457. PMID: 40461018; PMCID: PMC12799313. Abstract Acute ischemic stroke (AIS) is a life-threatening thrombotic disorder, […]

Arterial Thrombosis

January 2026 Cheat Sheet

Click here to read our January 2026 Cheat Sheet. The Cheat Sheet introduces and reviews our Quick Questions and presents current developments in hemostasis. If you would like a personal version of the Cheat Sheet featuring links to our January posts, please complete the form on the right. Precision BioLogic Inc. provides free access to […]

Cheat Sheets

February 2026 QQ: DOACs

Our February 2026 Quick Question is a quiz that asks, “Which DOAC is a direct thrombin inhibitor?” Since 2010, DOACs have become our primary antithrombotic agents prescribed for prophylaxis or therapy. While more DOACs are on the horizon, the current anticoagulants directly inhibit either thrombin or FXa. Please make your selection in the right-hand column […]

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Quick Question Archive

Jan 26 2026

george

January 2026 QQ Summary: Fibrinolysis

Our January 2026 QQ was a quiz that asked, “What fibrinolytic enzyme digests fibrin?” Here’s how our 34 respondents scored: D-dimer: 0 Plasmin 28 (82%) PAI-1: 2 (6%) TAFI 0 TPA 4 (12%) Congratulations on your successful answers. Here is a summary of fibrinolysis (figure), paraphrased from Walenga JM, Krum KN. Normal Hemostasis. In Keohane EM, […]

Fibrinolysis

World Thrombosis Day Article: Renal Vein Thrombosis

Click here for a World Thrombosis Day article about Renal Vein Thrombosis. Introduction Renal vein thrombosis is a blood clot that occurs in the veins draining blood from the kidneys. A blood clot in the renal vein will impact kidney function because it slows the flow of blood from the kidney and can reduce the […]

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Anticoagulant Therapy

Jan 24 2026

george

Low-dose Emicizumab Efficacy

Obtain this clinical research article on low-dose emicizumab therapy from your medical library: Datta G, Verma SP, Sinha S, et al. Bridging the Gap: Efficacy of low-dose emicizumab in haemophilia A with or without inhibitors. Haemophilia. 2026. doi: 10.1111/hae.70211. PMID: 41549560. ABSTRACT Introduction Emicizumab has proven to be a turning point in the management of […]

Bleeding Disorders

A Historical Review: Two Decades of Hemostasis and Thrombosis genetics

Here is an open-access review of the genetics of hemostasis: Sabater-Lleal M, Thibord F, de Vries PS, et al. Historical review: more than two decades of understanding the genetic architecture of hemostasis and thrombosis. J Thromb Haemost. 2025:S1538-7836(25)00845-1. doi: 10.1016/j.jtha.2025.11.006. PMID: 41352609. Abstract From the beginning of the millennium and the development of genome-wide analyses, […]

Coagulation Factors

VWD In Women: Non-bleeding Health Issues

Click to read this open-access article that addresses the reproductive, medical, skeletal, psychosocial, and economic impact of VWD in women. Swan D, Sholzberg M, Bannow BS, Thachil J. Von Willebrand disease: more than just a bleeding disorder. Res Pract Thromb Haemost. 2025;10:103276. doi: 10.1016/j.rpth.2025.103276. PMID: 41536292; PMCID: PMC12796595. Abstract Von Willebrand disease (VWD) is the […]

Bleeding Disorders

Diagnostic Equity: PB Platelets in Myelofibrosis

This question appeared on the Diagnostic Equity website on 1-21-2026: “How well do peripheral blood platelet findings correlate with bone marrow fibrosis or megakaryocyte abnormalities in myelofibrosis, and when do lab results suggest a marrow reassessment might be useful?” Diagnostic Equity expert Ryan J. Tom, MS, MLS(ASCP)CM (DCLS Resident) offered this answer: Platelet findings can […]

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Platelet Function Testing

All Posts

What is the MRX PT DOAC Assay?

Review: Neutrophil Extracellular Traps (NETs) in Thrombosis

January 2026 Cheat Sheet

February 2026 QQ: DOACs

January 2026 QQ Summary: Fibrinolysis

World Thrombosis Day Article: Renal Vein Thrombosis

Low-dose Emicizumab Efficacy

A Historical Review: Two Decades of Hemostasis and Thrombosis genetics

VWD In Women: Non-bleeding Health Issues

Diagnostic Equity: PB Platelets in Myelofibrosis

George Fritsma MS MLS

Cheat Sheets from George

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