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Oct 30 2025
george

Case Study: Measuring TAT Complex in LVAD Implantation

Check with your library for this article describing the TAT Assay in LVAD Implantation. Ling L, Liu C, Zhou J. Thrombin-antithrombin complex might be a promising parameter for monitoring anticoagulation in the early postoperative period after LVAD implantation. Lab Med. 2025 ;56:423–7. doi: 10.1093/labmed/lmae113. PMID: 40085520. Abstract Introduction: Appropriate bridging anticoagulation is critical in the […]
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Anticoagulant Therapy
Oct 29 2025
george

Two Cases of Brown Recluse Envenomation

Here is an open-access article that describes cases that illustrate the coagulopathy associated with brown recluse spider bites. Hart SA, Gailani D, Bibb LA, et al. Coagulation abnormalities following brown recluse spider (Loxosceles reclusa) envenomation: A description of 2 cases and review of the literature. Am J Clin Pathol. 2025;163:822–36. doi: 10.1093/ajcp/aqaf001. PMID: 39883062; PMCID: […]
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Thrombophilia
Oct 29 2025
george

PT and PTT Illustrated Mechanisms

For an illustrated overview of the hemostasis mechanisms associated with the PT and PTT, obtain this article from your medical library: Harris NS, Marin MJ, Butenas S. Beyond prothrombin time and activated partial thromboplastin time: coagulation in vivo-an illustrated review. Lab Med. 2025;56:438–47. doi: 10.1093/labmed/lmae125. PMID: 40319459. Abstract The steps that initiate coagulation in vivo […]
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Coagulation Factors
Oct 29 2025
george

Gene Transfer Therapy Updates

Yesterday, 10-28-25, we reported BioMarin’s press release announcing divestiture of their hemophilia A gene transfer therapy, valoctocogene roxaparvovec (Roctavian®). Previously, on February 25, 2025, Pfizer announced their intention to discontinue hemophilia B gene transfer therapy, fidanacogene elaparvovec-dzkt (Becvez®). Press releases from both indicate underperformance in sales. The remaining hemophilia B therapy, etranacogene dezaparvovec-drlb (HEMGENIX®), CSL […]
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Bleeding Disorders
Oct 28 2025
george

November 2025 QQ: Stuart-Prower Factor

Our November 2025 Quick Question tests our historical knowledge. Not long ago, we learned about various names for the coagulation factors; e. g., proaccelerin, proconvertin, and plasma thromboplastin antecedent. Some factor names were proper nouns, for example, Hageman factor, Fletcher factor, and Fitzgerald factor. This month’s question asks you to identify the Stuart-Prower factor by […]
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Quick Question Archive
Oct 27 2025
george

A Coag Conversation: Alternate Warfarin Monitoring When the Prothrombin Time is Unreliable – Part 1

Join me (Geo) and guest speaker Dr. Nicole Zantek, MD, PhD, Medical Director of the Special Coagulation Laboratory, Professor, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, who discusses the pathophysiology of antiphospholipid antibodies, and alternative methods to monitor warfarin and DOAC anticoagulation in patients diagnosed with antiphospholipid syndrome. This is the […]
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Anticoagulant Therapy
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George Fritsma MS MLS

George Fritsma is a medical laboratory scientist, educator, and author. George  is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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What VWD subtype Is caused by a VWF gain of function?