Feb 13 2026
Click here for the full news release from Flinders University News: New research, led by Flinders University and international experts, has finally uncovered how a rare blood-clotting condition can occur after some COVID-19 adenovirus-based vaccines or after a natural adenovirus infection.
First paragraph: To the Editor:
Disorders caused by antibodies against platelet factor 4 (PF4) gained major attention during the pandemic, when platelet-activating anti-PF4 antibodies were found to explain vaccine-induced immune thrombocytopenia and thrombosis (VITT) after coronavirus disease 2019 (Covid-19) vaccination with two adenoviral vector–based vaccines, ChAdOx1 nCoV-19 (Oxford–AstraZeneca) and Ad26.COV2.S (Johnson & Johnson–Janssen). Affected patients often have multiple or unusual sites of thromboses, such as the cerebral venous sinus and splanchnic veins, with high levels of d-dimer.
Click here for the open-access letter to the editor: Wang JJ, Schönborn L, Warkentin TE, Chataway T, Grosse L, Simioni P, Moll S, Greinacher A, Gordon TP. Antibody fingerprints linking adenoviral anti-PF4 disorders. N Engl J Med. 2024;390:1827-1829. doi: 10.1056/NEJMc2402592. PMID: 38749041.
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