Whole Blood Lumiaggregometry

From Heather DeVries, Indiana University Health: We currently perform our platelet aggregations using PRP, but would like to investigate whole blood aggregometry. Our pathologist feels that if we do that, we should also look into lumiaggregometry. He does agree that it would improve our sensitivity to platelet functions disorders (i.e. storage pool disease), but wanted […]

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Platelet Function Testing

Feb 9 2017

george

Polycythemia and Anticoagulant Volume

From Heather DeVries, Indiana University Health: Greetings George! A couple of sites within our system are evaluating our process for correcting tubes. One mentioned CLSI guidelines, and when I looked, they keep it very simple, saying that removal of 0.1 mL of citrate will cover hematocrits between 55 and 65%. Historically, we have calculated to […]

Specimen Management

Off Label Low Dose DOACs

Click or tap here for Dr. Samual Goldhaber’s video clip describing the prevalence of off-label low dosing of dabigatran, rivaroxaban, and apixaban.

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Anticoagulant Therapy

Jan 24 2017

george

Diluting Chromogenic Anti-Xa’s For Heparin

From Denise Jones: Good afternoon George, A colleague of mine recently questioned why we were diluting our anti-Xa heparins and anti-Xa LMWHs. We do not dilute Arixtra or rivaroxaban. What is standard practice for other labs? We use Stago Liquid Anti-Xa reagent and a hybrid curve. Thank you. Hi, Denise, the specimen dilutions for chromogenic […]

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Anticoagulant Therapy

Jan 20 2017

george

IL Acquires Accriva

Today, January 20, 2017, Werfen (Barcelona) and their partner, Instrumentation Laboratory (IL, New Bedford, MA), announced their acquisition of Accriva Diagnostics of San Diego. Accriva manufactures and distributes the Hemochron coagulation testing instrument, which performs point of care PT/INR, PTT, and ACT assays, and the VerifyNow antiplatelet therapeutic efficacy device. Click or tap here for […]

Events

2017 NASTH Fellowship

Second notice, forwarded on behalf of the North American Society on Thrombosis and Hemostasis: Dear NASTH Members, The deadline for Mentor Requests for the 2017 Fellowships is extended to February 10. We are in the midst of our application period for the 2017 NASTH Sponsored Research Fellowships, an 8 – 10 week program for […]

Events

Apixaban After TAVR in AF

A January, 2017 publication indicates that apixaban (Eliquis) yields fewer bleeds, less kidney damage, and fewer strokes in patients with atrial fibrillation after transfemoral aortic valve replacement (TAVR) over the first 30 days of treatment. See Seeger J, Gonska B, Rodewald C, Rottbauer W, Wöhrle J. Apixaban in patients with atrial fibrillation after transfemoral aortic valve replacement (TAVR). JACC: Cardiovascular Interventions 2017;10: DOI: […]

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Anticoagulant Therapy

Jan 12 2017

george

What is SEER Sonorheometry?

A colleague saw our January 10, 2017 entry describing T2MR, an emerging global hemostasis methodology, and responded with information about sonic estimation of elasticity via resonance (SEER) sonorheometry, a non-contact technology that employs ultrasound to measure whole blood parameters similar to the viscoelasticity data generated in thromboelastography (TEG) and thromboelastometry (TEM). The technology measures acoustic […]

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Global Hemostasis Assays

Jan 11 2017

george

More on ISTAT Versus PT/INr

Here is a Paul Riley, PhD follow up to Diane Treadway’s discussion and follow-up comment comparing the ISTAT INR to the central lab plasma-based PT/INR. From Dr. Riley, Stago-US. I don’t understand what is happening with the bivalirudin interference. According to Gosselin et al. (below) there should be minimal effect on the Stago PT (see […]

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Anticoagulant Therapy

Jan 10 2017

george

What is T2MR?

You may be hearing about the emerging diagnostic nanotechnology, T2 Magnetic Resonance (T2MR). Here is a summary of this intriguing new methodology that promises to revolutionize hemostasis testing. T2MR instruments are point of care devices that employ a permanent magnet assembly, radiofrequency probe, and a recording mechanism that measures the spin-spin (T2) relaxation times of […]

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Global Hemostasis Assays

All Posts

Whole Blood Lumiaggregometry

Polycythemia and Anticoagulant Volume

Off Label Low Dose DOACs

Diluting Chromogenic Anti-Xa’s For Heparin

IL Acquires Accriva

2017 NASTH Fellowship

Apixaban After TAVR in AF

What is SEER Sonorheometry?

More on ISTAT Versus PT/INr

What is T2MR?

George Fritsma MS MLS

Cheat Sheets from George

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