From Kerri Klemm: Has anyone had problems recently with ristocetin-induced platelet aggregation? We have used this reagent for years and just recently had problems. We run the ristocetin at 1.5 mg, which should react and does and 0.75 mg, which shouldn’t react but does. This is with our normal controls who we have used before. Until recently we got the expected reactions but now everyone reacts at 0.75. We tried a different brand and it seems to work better. But the brand we were using we started using a few years ago when the previous brand did the same thing. This has happened with different patients and controls and every tech in the department. Any insight would be greatly appreciated.
Thank you, Kerri, I’ve not heard of any problems, however we are likely to hear from some of our participants. Geo