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Validating a Rapid HIT Assay

Charlie MullerHelen Hayes Hospital TW, posted a question on the Medlab list, paraphrased here with his permission. He is validating the Akers PIFA Heparin/PF4 rapid assay kit for heparin induced thrombocytopenia with thrombosis, and needs a good way to validate it in addition to using Akers’ panels. Charlie’s setting is an acute rehab specialty hospital where a very large majority of patients have been exposed to heparin in various surgical procedures. They consult with a pathologist from Columbia University Medical Center who has had several discussions with the medical staff about HIT being a clinical diagnosis, using Warkentin’s 4T, etc. The staff want a little extra guidance from a rapid lab test.

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