Here are the unsurprising resuts of our June, 2018 Quick Question, “How do you measure factor VIII therapy?”
- Clot-based factor assay: 82% (36)
- Immunoassay: 5% (2)
- Chromogenic substrate: 14% (6)
Dave McGlasson suggested this question because our current clot-based methods are unreliable when assaying for synthetic B-domain deleted and extended half-life preparations, many of which are also B-domain deleted. Our clot-based assays, which have always suffered from imprecision, are relatively inaccurate when measuring the newer synthetic concentrates. A number of rresearchers are now developing new, more accurate measures that we will be reporting on as they are developed.