Dear George, I work in a large midwest reference laboratory. We are looking at bringing in the Prot S free latex test. Have you seen any comparison studies between manufacturers’ kits that I could go out on the internet and read? Thanks, Pamela L. Pool, Section Specialist for Coagulation.
Hello, Pamela, thank you for your question. Yes, please access Mulder R, Ten Kate MK, Kluin-Nelemans HC, Mulder AB. Low cut-off values increase diagnostic performance of protein S assays. Thromb Haemost 2010;104:618–25. This group has examined the predictive values of several protein S activity and antigen assays. Also, I invite our participants to provide their favorite references or local comparison studies. Geo.
Dear Pamela, I work for SNP, a large private pathology in Au
Dear Pamela, I work for SNP, a large private pathology in Australia. We have used in the past the Stago LIA free S and have recently changed to the Siemens Free S Antigen. Both kits have performed well, were simple to use, had good CV and performed well in external QAP. It depends on your instrumentation which is easier for you. We do have a clot based S for very rare occasions we need to confirm a Free S result or suspect dysfunctional genotype. Regards Robyn
External Quality Assurance of Antithrombin, Protein C,and Pr
External Quality Assurance of Antithrombin, Protein C,and Protein S Assays: Results of the College of American Pathologists Proficiency Testing Program in Thrombophilia.