A colleague asked George, can you please suggest a commercial normal and abnormal control one can use to test an assay that claims to distinguish normal from abnormal platelet function. Alternatively, suggest also please for preparing controls for research testing purposes. Specifically, how can we go about preparing a normal activity platelet control and an abnormal activity platelets control for research use.
I received a response from colleague and consultant Kirk Guyer, who wrote, unfortunately there are no commercial controls available for platelet function. A laboratory must identify a healthy normal individual from whom they may draw a fresh blood sample and test within three hours. Platelets have a short lifespan outside of the body. Depending on the agonist that is going to be tested, a specific antagonist such as aspirin may be added to the sample in-vitro to produce an abnormal sample to a specific agonist such as arachidonic acid.