February, 2022 Quick Question: Platelet Aggs

February, 2022 Quick Question: Platelet Aggs
Jan 30, 2022 4:18pm

Our February 2022 Quick Question asks, What single agonist is your first choice to measure platelet response to aspirin? The typical aggregation profile includes several agonists, however it may be that one is more sensitive to aspirin's antiplatelet effect than the others. As always, please add your comments below.

1 Comment

Our February 2022 Quick Question asks, What single agonist is your first choice to measure platelet response to aspirin? The typical aggregation profile includes several agonists, however it may be that one is more sensitive to aspirin's antiplatelet effect than the others. As always, please add your comments below.

By Coag Research Dave McGlasson
Feb 2, 2022 10:55am
I would always start with a concentration of arachidonic acid for measuring the effect of aspirin on platelet aggregation. See McGlasson DL, Fritsma GA. Comparison of four laboratory methods to assess aspirin sensitivity. Blood Coag Fibrinolysis 2008; 19:120–3 and Schwertner HA, McGlasson DL, Bush A. Effects of different aspirin formulations on platelet aggregation times and on plasma salicylate concentrations. Thrombosis Research 2006; 118: 529–34.

Leave A Comment

You must be logged in to Comment - Sign In