Feb, 2020 Quick Question: Chronic Bleeding

Feb, 2020 Quick Question: Chronic Bleeding
Mar 1, 2020 7:52pm

Our February, 2020 Quick Question, which drew 114 answers, asks, "For chronic bleeds, poor wound healing with normal PT , PTT , FG and platelets, what assay should be next?"

Answers:

  1. Factor VIII: 18% (21)
  2. Factor IX: 3% (3)
  3. Factor XI: 4% (5)
  4. Factor XIII: 75% (85)

The question was meant to draw us to factor XIII deficiency as it references poor wound healing. In defense of those who chose factor VIII deficiency as a possibility, a moderately low factor VIII level may not necessarily prolong the PTT in cases where the PTT is conservatively calibrated to prolong at levels below 30 U/dL. However, given the normal platelet parameters, factor XIII deficiency is the most likely situation.

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Our February, 2020 Quick Question, which drew 114 answers, asks, "For chronic bleeds, poor wound healing with normal PT , PTT , FG and platelets, what assay should be next?"

Answers:

  1. Factor VIII: 18% (21)
  2. Factor IX: 3% (3)
  3. Factor XI: 4% (5)
  4. Factor XIII: 75% (85)

The question was meant to draw us to factor XIII deficiency as it references poor wound healing. In defense of those who chose factor VIII deficiency as a possibility, a moderately low factor VIII level may not necessarily prolong the PTT in cases where the PTT is conservatively calibrated to prolong at levels below 30 U/dL. However, given the normal platelet parameters, factor XIII deficiency is the most likely situation.

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