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New DOAC Reversal Agents

George, I noticed on Fritsma Factor the question on using Kcentra to reverse DOACs.  I just got this off Medscape on a phase 3 study of an antidote to the  factor Xa inhibitor apixaban. An IV bolus of andexanet alfa immediately and significantly reversed apixaban in 33 healthy volunteers enrolled in the ANNEXA-A study.  The authors also state that Idarucizumab reverses the oral thrombin inhibitor dabagatran etexilate mesylate.  Both have FDA breakthrough status.
David L. McGlasson, GS-13
Clinical Research Scientist

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