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More on FVIII Linearity

I spoke with Patti TichenorUAB special coagulation laboratory who had discussed our December 5, 2012 factor VIII linearity question from Mahnaz Sairi with her UAB colleague Laura Taylor. UAB uses high-end coagulometers (Stago STA-R) for their factor assays, and their linearity extends from near zero to 100%. When they anticipate especially high factor VIII levels, they will order dilutions to as high as 1:60 (recall the initial dilution is 1:10). Using this method, they recently report a FVIII activity level of over 700% on a renal failure patient.

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