Register Login

DRVVT Ratio Normalization

In reviewing an article by Dave McGlasson, Wilford Hall USAF Medical Center, San Antonio, that compares several dilute Russell viper venom (DRVVT) kits for their accuracy in detecting lupus anticoagulant, I noticed that Dave advocates for DRVVT ratio normalization, using the attached formula. I may be behind the times, but this is a new concept to me, and it seems to lend greater accuracy to DRVVT reports. Are you using DRVVT ratio normalization? Does it improve your sensitivity and specificity figures?

DRVVT Normalization Ratio

Thanks to a heads-up from Stephen Duff, Co-CEO of Precision BioLogic, please seeZhang L, Whitis JG, Embry MB, Hollensead SC. A simplified algorithm for the laboratory detection of lupus anticoagulants: utilization of two automated integrated tests. Am J Clin Pathol 2005;124:894–901, the original article on this subject.

Comments (0)
Lupus Anticoagulant

No comments here.

Leave a Reply