George participates in CLSC5124E-Sp14; Advanced Hemostasis, a graduate course offered by Drs. Nadine Fydryszewski and Elaine Keohane of Rutgers University School of Biomedical and Health Sciences. The faculty also include Dr. Larry Smith and Prof.Donna Castellone. This course attracts experienced medical laboratory scientists from around the world who raise interesting questions, including this one about transient gestations protein S deficiency:
A surfeit of studies have linked gestational thrombophilia and fetal loss with factor V Leiden and prothrombin 20210 mutations, congenital antithrombin, protein C, and protein S deficiency, antiphospholipid syndrome, and in particular, eclampsia. We also know that for many women, the free protein S concentration drops, often to below the lower limit of the reference interval, during pregnancy. This is a transient, perhaps inflammation-related occurrence, and does not imply an inherited thrombosis risk factor. However, is the temporary free protein S deficiency an independent risk factor for thrombosis? Should the obstetrician consider anticoagulant therapy while the protein S is low? Have any of our Fritsma Factor participants seen studies linking transient gestational protein S deficiency with thrombosis or fetal loss? The inquiring minds of our graduate students want to know.