From Crystal Azevedo: I am currently evaluating the ECA-T kit to monitor dabigatran therapy. Are you aware of any labs/companies that have a set of validation plasmas?
Sorry, Crystal, but no one is currently distributing dabigatran calibrators or controls, including the product developers at Diagnostica Stago, who have developed the research use only ecarin clotting assay (ECA) for monitoring the direct thrombin inhibitors bivalirudin, argatroban, and dabigatran. (Lepirudin was withdrawn in May, 2012.) We’ll continue to watch the usual plasma distributors Precision BioLogic, Inc and George King Biologicals, among others, for developments.
It is no consolation to you, of course, but on July 16 Stago released information on its new rivaroxaban (Xarelto®) calibrators and controls, designed for use with their anti-Xa assay, according to Paul Riley, PhD, Stago’s Manager of Research Use Products. Here is their brochure and press release:
Dabigatran Plasma Calibrator (222801) and Control (224701) f
Dabigatran Plasma Calibrator (222801) and Control (224701) from Hyphen Biomed