Cell-based Coagulation Model

Our Coagulation Overview Module, linked on May 15, 2026, may be more accurately called the Plasma-based Coagulation Overview Module. The plasma-based coagulation “cascade” model, described in Davie EW, Fujikawa K, Kisiel W. The coagulation cascade: initiation, maintenance, and regulation. Biochemistry. 1991;30:10363–70. doi: 10.1021/bi00107a001. PMID: 1931959, is the basis for clot-based tests, the PT, PTT, TT, and factor assays. The advanced Cell-based Coagulation model, Roberts HR, Hoffman M, Monroe DM. A cell-based model of thrombin generation. Semin Thromb Hemost. 2006;32 Suppl 1:32-8. doi: 10.1055/s-2006-939552. PMID: 16673264 more closely reflects hemostatic physiology, which occurs on cells, not in free plasma. The cell-based mechanism also connects hemostasis to inflammatory mechanisms. Navigate to our educational module, Cell-based Coagulation, for an introduction. At first glance, the cell-based module may appear more complex than the plasma-based module, but you can pause the progression with your space bar. The module is based on the Cell-based Physiologic Coagulation section by Walenga JM and Krum KN. Normal Hemostasis in Keohane EM, Butina MM, Mirza KM, Walenga JM. Rodak’s Hematology: Clinical Principles and Applications, Seventh Edition, Elsevier, 2025.