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Thrombophilia

Nov 12 2025
george

Alternate Functions of AT, PC, PS, and TFPI

Go to your medical library to download the meta-analysis Prouse T, Mast AE, Ignjatovic V, Kovac M, Bereczky Z, Majumder R. Alternate functions of physiological anticoagulants. J Thromb Haemost. 2025:S1538-7836(25)00540-9. doi: 10.1016/j.jtha.2025.08.014. PMID: 40907701. Abstract The anticoagulant proteins antithrombin, protein C, protein S, and tissue factor pathway inhibitor are physiological regulators of the blood coagulation […]
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Thrombophilia
Oct 31 2025
george

Analysis of Antiphospholipid Antibody Testing

Select an open-access article, Thirunavukarasu C, PasalicL, Favaloro EJ. A contemporary analysis of solid-phase antiphospholipid antibody testing: implications for classification or diagnosis of antiphospholipid syndrome, Pathology, https://doi.org/10.1016/j.pathol.2025.07.003   for a look at current ACL and anti β-2 glycoprotein 1 assays and their efficacy in diagnosing APS. Abstract Antiphospholipid antibody (aPL) testing is required for diagnosis of […]
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Thrombophilia
Oct 29 2025
george

Two Cases of Brown Recluse Envenomation

Here is an open-access article that describes cases that illustrate the coagulopathy associated with brown recluse spider bites. Hart SA, Gailani D, Bibb LA, et al. Coagulation abnormalities following brown recluse spider (Loxosceles reclusa) envenomation: A description of 2 cases and review of the literature. Am J Clin Pathol. 2025;163:822–36. doi: 10.1093/ajcp/aqaf001. PMID: 39883062; PMCID: […]
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Thrombophilia
Oct 27 2025
george

A Coag Conversation: Alternate Warfarin Monitoring When the Prothrombin Time is Unreliable – Part 1

Join me (Geo) and guest speaker Dr. Nicole Zantek, MD, PhD, Medical Director of the Special Coagulation Laboratory, Professor, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, who discusses the pathophysiology of antiphospholipid antibodies, and alternative methods to monitor warfarin and DOAC anticoagulation in patients diagnosed with antiphospholipid syndrome. This is the […]
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Anticoagulant Therapy
Sep 19 2025
george

A Relationship Between Radiotherapy and Venous Thrombosis

Click here for an open-access 2025 article that describes the relationship between radiotherapy and cancer-associated venous thrombosis: Gurumurthy G, Miller J, Carrier M, Khorana A, Thachil J. Radiotherapy-the not-so-insignificant contributor to cancer-associated venous thrombosis. Res Pract Thromb Haemost. 2025;9:102985. doi: 10.1016/j.rpth.2025.102985. PMID: 40837025; PMCID: PMC12362088. Abstract Venous thromboembolism is a well-established complication in patients with […]
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Thrombophilia
Sep 10 2025
george

APL Positivity Cutoffs: 99th Percentile?

For a fresh look at anticardiolipin antibody and anti-β2-GP1 analysis decision points, click Anunciación-Llunell A, Marques-Soares J, Ockova M, et al. The absence of standardization in antiphospholipid antibody testing may favor the use of 99th percentile cutoffs in antiphospholipid syndrome classification. Res Pract Thromb Haemost. 2025;9:102967. doi: 10.1016/j.rpth.2025.102967. PMID: 40761700; PMCID: PMC12320162.
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Thrombophilia
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George Fritsma MS MLS

George Fritsma is a medical laboratory scientist, educator, and author. George  is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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What VWD subtype Is caused by a VWF gain of function?