What is Red Light Therapy?

Check with your medical library for this in-depth review of red light Rx efficacy: Fan BE, Pasalic L, Hew YY, Lippi G, Favaloro EJ. Red light therapy in thrombosis and hemostasis. Semin Thromb Hemost. 2026;52:266–72. doi: 10.1055/a-2717-5157. PMID: 41062078. Abstract Red light therapy is emerging as a potential non-pharmacological modulator of thrombosis and hemostasis. Photobiomodulation […]

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Antiplatelet Therapy

Feb 9 2026

george

Normalized Activated Protein C Sensitivity Ratio Predicts VTE in OCR

Here is an open-access report on a noteworthy primary research piece detailing an assay that predicts VTE risk associated with oral contraceptives: Morimont L, Creinin MD, Gaspard U, Foidart JM, and Douxfils J. Predicting venous thromboembolism risk from an endogenous thrombin potential-based normalized activated protein C sensitivity ratio assay: toward early assessment of combined oral […]

Thrombophilia

ADAMTS-13 Conformation

What if we’ve been monitoring the wrong biomarker in iTTP remission? In immune-mediated TTP, we obsess over ADAMTS13 activity to predict relapse. But what if activity isn’t the earliest warning sign? A fascinating new study suggests the real signal may be hiding in ADAMTS13 conformation. Here is the open-access link: Joly BS, Roose E, Dekimpe […]

Thrombophilia

Thrombophilia Testing After Provoked DVT

Following 2023 ASH guidelines, should facilities proceed with thrombophilia screening for patients who develop VTE following transient triggers? Here is an open-access essay on the effects of the ASH guidelines that appears in the January 1, 2026, issue of Clinical Laboratory News, an ADLM publication. Click “Does Provoked VTE Warrant Thrombophilia Testing?“

Thrombophilia

Review: Neutrophil Extracellular Traps (NETs) in Thrombosis

This open-access review scans literature associating NETs with coagulation: Huang G, Wu H, Lin B, et al. Targeting neutrophil extracellular traps: a new strategy for the treatment of acute ischemic stroke based on thrombolysis resistance. Semin Thromb Hemost. 2026;52:80-91. doi: 10.1055/a-2609-3457. PMID: 40461018; PMCID: PMC12799313. Abstract Acute ischemic stroke (AIS) is a life-threatening thrombotic disorder, […]

Arterial Thrombosis

World Thrombosis Day Article: Renal Vein Thrombosis

Click here for a World Thrombosis Day article about Renal Vein Thrombosis. Introduction Renal vein thrombosis is a blood clot that occurs in the veins draining blood from the kidneys. A blood clot in the renal vein will impact kidney function because it slows the flow of blood from the kidney and can reduce the […]

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Anticoagulant Therapy

Jan 24 2026

george

A Historical Review: Two Decades of Hemostasis and Thrombosis genetics

Here is an open-access review of the genetics of hemostasis: Sabater-Lleal M, Thibord F, de Vries PS, et al. Historical review: more than two decades of understanding the genetic architecture of hemostasis and thrombosis. J Thromb Haemost. 2025:S1538-7836(25)00845-1. doi: 10.1016/j.jtha.2025.11.006. PMID: 41352609. Abstract From the beginning of the millennium and the development of genome-wide analyses, […]

Coagulation Factors

Meta-analysis: D-dimer Safely Excludes Pulmonary Embolism in Cancer

Obtain this provocative article from your medical library: Vrotniakaite-Bajerciene K, Mallick R, Takada T, et al. Safety and efficiency of D-dimer testing in combination with clinical decision rules to exclude pulmonary embolism in patients with cancer: individual patient data meta-analysis. J Thromb Haemost. 2025:S1538-7836(25)00839-6. doi: 10.1016/j.jtha.2025.10.035. PMID: 41354153. Abstract Background: Failure rates of clinical decision […]

Thrombophilia

Pilot Study: Oxerutin Therapy for Post-thrombotic Syndrome

Select this link to an open-access pilot study describing oxerutin, which is designed to reduce venous blockage after DVT: Iding AFJ, Hupperetz RD, Brans RJB, et al. Additional oxerutin therapy to promote deep vein thrombus resolution (RESOLVE-DVT): a randomized controlled pilot trial. J Thromb Haemost. 2025:S1538-7836(25)00718-4. doi: 10.1016/j.jtha.2025.10.018. PMID: 41197809. Abstract Background: Postthrombotic syndrome (PTS) […]

Thrombophilia

December 2025 QQ Results: Control Proteins

Our December 2025 Quick Question was a quiz that asked, “What plasma control protein acts against FIIa & FXa?” Here’s how our 34 respondents fared… Antithrombin: 27 (79%) Protein C: 5 (15%) Protein S: 1 (3%) Protein Z: 0 TFPI: 1 (3%) We scored well on this question. Antithrombin (AT), when activated by therapeutic heparin […]

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Coagulation Factors

Thrombophilia

What is Red Light Therapy?

Normalized Activated Protein C Sensitivity Ratio Predicts VTE in OCR

ADAMTS-13 Conformation

Thrombophilia Testing After Provoked DVT

Review: Neutrophil Extracellular Traps (NETs) in Thrombosis

World Thrombosis Day Article: Renal Vein Thrombosis

A Historical Review: Two Decades of Hemostasis and Thrombosis genetics

Meta-analysis: D-dimer Safely Excludes Pulmonary Embolism in Cancer

Pilot Study: Oxerutin Therapy for Post-thrombotic Syndrome

December 2025 QQ Results: Control Proteins

George Fritsma MS MLS

Cheat Sheets from George

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