Review: Neutrophil Extracellular Traps (NETs) in Thrombosis

This open-access review scans literature associating NETs with coagulation: Huang G, Wu H, Lin B, et al. Targeting neutrophil extracellular traps: a new strategy for the treatment of acute ischemic stroke based on thrombolysis resistance. Semin Thromb Hemost. 2026;52:80-91. doi: 10.1055/a-2609-3457. PMID: 40461018; PMCID: PMC12799313. Abstract Acute ischemic stroke (AIS) is a life-threatening thrombotic disorder, […]

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Arterial Thrombosis

Jan 25 2026

george

World Thrombosis Day Article: Renal Vein Thrombosis

Click here for a World Thrombosis Day article about Renal Vein Thrombosis. Introduction Renal vein thrombosis is a blood clot that occurs in the veins draining blood from the kidneys. A blood clot in the renal vein will impact kidney function because it slows the flow of blood from the kidney and can reduce the […]

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Anticoagulant Therapy

Jan 24 2026

george

A Historical Review: Two Decades of Hemostasis and Thrombosis genetics

Here is an open-access review of the genetics of hemostasis: Sabater-Lleal M, Thibord F, de Vries PS, et al. Historical review: more than two decades of understanding the genetic architecture of hemostasis and thrombosis. J Thromb Haemost. 2025:S1538-7836(25)00845-1. doi: 10.1016/j.jtha.2025.11.006. PMID: 41352609. Abstract From the beginning of the millennium and the development of genome-wide analyses, […]

Coagulation Factors

Meta-analysis: D-dimer Safely Excludes Pulmonary Embolism in Cancer

Obtain this provocative article from your medical library: Vrotniakaite-Bajerciene K, Mallick R, Takada T, et al. Safety and efficiency of D-dimer testing in combination with clinical decision rules to exclude pulmonary embolism in patients with cancer: individual patient data meta-analysis. J Thromb Haemost. 2025:S1538-7836(25)00839-6. doi: 10.1016/j.jtha.2025.10.035. PMID: 41354153. Abstract Background: Failure rates of clinical decision […]

Thrombophilia

Pilot Study: Oxerutin Therapy for Post-thrombotic Syndrome

Select this link to an open-access pilot study describing oxerutin, which is designed to reduce venous blockage after DVT: Iding AFJ, Hupperetz RD, Brans RJB, et al. Additional oxerutin therapy to promote deep vein thrombus resolution (RESOLVE-DVT): a randomized controlled pilot trial. J Thromb Haemost. 2025:S1538-7836(25)00718-4. doi: 10.1016/j.jtha.2025.10.018. PMID: 41197809. Abstract Background: Postthrombotic syndrome (PTS) […]

Thrombophilia

December 2025 QQ Results: Control Proteins

Our December 2025 Quick Question was a quiz that asked, “What plasma control protein acts against FIIa & FXa?” Here’s how our 34 respondents fared… Antithrombin: 27 (79%) Protein C: 5 (15%) Protein S: 1 (3%) Protein Z: 0 TFPI: 1 (3%) We scored well on this question. Antithrombin (AT), when activated by therapeutic heparin […]

Coagulation Factors

Clinical Research Study: Andexanet Alfa for Enoxaparin Reversal

Navigate to this open-access article describing andexanet alfa reversal of LMWH: van Haaps TF, Benz AP, Xu L, Middeldorp S, Eikelboom JW, et al. Andexanet alfa for the reversal of the low-molecular-weight heparin enoxaparin. Res Pract Thromb Haemost. 2025;9:103191. doi: 10.1016/j.rpth.2025.103191. PMID: 41141842; PMCID: PMC12552982. Abstract Background Andexanet alfa (andexanet) is the only approved reversal […]

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Anticoagulant Therapy

Dec 26 2025

george

Analytical Dilemmas in Lupus Anticoagulant Testing

Click here to read an open-access review by Moore GW. Analytical Dilemmas in Lupus Anticoagulant Testing. Explor Immunol. 2023;3:300–24 DOI: https://doi.org/10.37349/ei.2023.00104 Abstract Accurate lupus anticoagulant (LA) detection is crucial to antiphospholipid syndrome (APS) diagnosis. Detection is based on LA functional behavior in coagulation assays irrespective of epitope specificity. LA screening tests employ dilute phospholipids to […]

Arterial Thrombosis

Discussion of Phase I Data on a Unique anti-VWF Thrombolytic

A summary by Dr. Wolfgang Miesbach: A potential landmark thrombolytic innovation presented at ASH 2025. Thrilled by the exciting Phase 1 data presentation by Marie Scully and co-authors on TGD001, a groundbreaking novel von Willebrand factor (VWF)-targeting thrombolytic: First-of-its-kind mechanism: TGD001 is an antibody-enzyme fusion protein—specifically, an anti-VWF antibody fragment fused to a urokinase catalytic domain. […]

Arterial Thrombosis

Editorial: Thrombophilia Diagnosis–Genetic or Functional Testing

Check with your medical library for Favaloro EJ, Moore GW, Pasalic L. Diagnosing thrombophilia: the case for genetic or functional testing? Expert Rev Mol Diagn. 2025:1-6. doi: 10.1080/14737159.2025.2588621. PMID: 41211955. Introduction The term thrombophilia defines a condition in which there is an elevated risk of thrombosis, usually venous thromboembolism (VTE), generally encompassing deep vein thrombosis […]

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Thrombophilia

Thrombophilia

Review: Neutrophil Extracellular Traps (NETs) in Thrombosis

World Thrombosis Day Article: Renal Vein Thrombosis

A Historical Review: Two Decades of Hemostasis and Thrombosis genetics

Meta-analysis: D-dimer Safely Excludes Pulmonary Embolism in Cancer

Pilot Study: Oxerutin Therapy for Post-thrombotic Syndrome

December 2025 QQ Results: Control Proteins

Clinical Research Study: Andexanet Alfa for Enoxaparin Reversal

Analytical Dilemmas in Lupus Anticoagulant Testing

Discussion of Phase I Data on a Unique anti-VWF Thrombolytic

Editorial: Thrombophilia Diagnosis–Genetic or Functional Testing

George Fritsma MS MLS

Cheat Sheets from George

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