Here is a question from my colleague Dr. Jeanine Walenga at Loyola University Medical Center in Chicago: Dear George, Is there data on whether beta-2-glycoprotein 1 (β2GP1) interferes in the serotonin release assay (SRA) for heparin-induced thrombocytopenia (HIT) testing? Hello, Jeanine, and thank you for your question, which drove me to the books, PubMed, and ultimately to Dr. […]

From Pam Owens at Tricore: We have a specimen from a pregnant patient with a low clottable protein C. Her INR is normal, but she is a heterozygote for both factor V Leiden mutation and the prothrombin 20120 gene mutation. Could the prothrombin gene mutation be interfering with the assay, causing the PC levels to appear lower than they actually […]