Feb 13 2026

george

Letter to 2024 NEJM Links Adenoviral Anti-PF4 to VITT

Click here for the full news release from Flinders University News: New research, led by Flinders University and international experts, has finally uncovered how a rare blood-clotting condition can occur after some COVID-19 adenovirus-based vaccines or after a natural adenovirus infection. First paragraph: To the Editor: Disorders caused by antibodies against platelet factor 4 (PF4) gained […]

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Arterial Thrombosis

Feb 13 2026

george

A History of Russell Viper Venom

Here’s an amusing history of RVV and Dr. Russell, who named the venom. You may retrieve the article from your medical library. Thachil J. Russell viper venom: a journey from the bedside to the bench and back to the bedside. Semin Thromb Hemost. 2024;50:115-118. doi: 10.1055/s-0043-1771269.  PMID: 37506733. Abstract Russell Viper Venom (RVV) is widely […]

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Anticoagulant Therapy

Feb 13 2026

george

What is Red Light Therapy?

Check with your medical library for this in-depth review of red light Rx efficacy: Fan BE, Pasalic L, Hew YY, Lippi G, Favaloro EJ. Red light therapy in thrombosis and hemostasis. Semin Thromb Hemost. 2026;52:266–72. doi: 10.1055/a-2717-5157. PMID: 41062078. Abstract Red light therapy is emerging as a potential non-pharmacological modulator of thrombosis and hemostasis. Photobiomodulation […]

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Antiplatelet Therapy

Feb 9 2026

george

Normalized Activated Protein C Sensitivity Ratio Predicts VTE in OCR

Here is an open-access report on a noteworthy primary research piece detailing an assay that predicts VTE risk associated with oral contraceptives: Morimont L, Creinin MD, Gaspard U, Foidart JM, and Douxfils J. Predicting venous thromboembolism risk from an endogenous thrombin potential-based normalized activated protein C sensitivity ratio assay: toward early assessment of combined oral […]

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Thrombophilia

Feb 7 2026

george

ADAMTS-13 Conformation

What if we’ve been monitoring the wrong biomarker in iTTP remission? In immune-mediated TTP, we obsess over ADAMTS13 activity to predict relapse. But what if activity isn’t the earliest warning sign? A fascinating new study suggests the real signal may be hiding in ADAMTS13 conformation. Here is the open-access link: Joly BS, Roose E, Dekimpe […]

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Thrombophilia

Feb 4 2026

george

Thrombophilia Testing After Provoked DVT

Following 2023 ASH guidelines, should facilities proceed with thrombophilia screening for patients who develop VTE following transient triggers? Here is an open-access essay on the effects of the ASH guidelines that appears in the January 1, 2026, issue of Clinical Laboratory News, an ADLM publication. Click “Does Provoked VTE Warrant Thrombophilia Testing?“

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Thrombophilia

Jan 30 2026

george

Review: Neutrophil Extracellular Traps (NETs) in Thrombosis

This open-access review scans literature associating NETs with coagulation: Huang G, Wu H, Lin B, et al. Targeting neutrophil extracellular traps: a new strategy for the treatment of acute ischemic stroke based on thrombolysis resistance. Semin Thromb Hemost. 2026;52:80-91. doi: 10.1055/a-2609-3457. PMID: 40461018; PMCID: PMC12799313. Abstract Acute ischemic stroke (AIS) is a life-threatening thrombotic disorder, […]

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Arterial Thrombosis

Jan 25 2026

george

World Thrombosis Day Article: Renal Vein Thrombosis

Click here for a World Thrombosis Day article about Renal Vein Thrombosis. Introduction Renal vein thrombosis is a blood clot that occurs in the veins draining blood from the kidneys. A blood clot in the renal vein will impact kidney function because it slows the flow of blood from the kidney and can reduce the […]

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Anticoagulant Therapy

Jan 24 2026

george

A Historical Review: Two Decades of Hemostasis and Thrombosis genetics

Here is an open-access review of the genetics of hemostasis: Sabater-Lleal M, Thibord F, de Vries PS, et al. Historical review: more than two decades of understanding the genetic architecture of hemostasis and thrombosis. J Thromb Haemost. 2025:S1538-7836(25)00845-1. doi: 10.1016/j.jtha.2025.11.006. PMID: 41352609. Abstract From the beginning of the millennium and the development of genome-wide analyses, […]

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Coagulation Factors

Jan 23 2026

george

Meta-analysis: D-dimer Safely Excludes Pulmonary Embolism in Cancer

Obtain this provocative article from your medical library: Vrotniakaite-Bajerciene K, Mallick R, Takada T, et al. Safety and efficiency of D-dimer testing in combination with clinical decision rules to exclude pulmonary embolism in patients with cancer: individual patient data meta-analysis. J Thromb Haemost. 2025:S1538-7836(25)00839-6. doi: 10.1016/j.jtha.2025.10.035. PMID: 41354153. Abstract Background: Failure rates of clinical decision […]

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Thrombophilia