Quick Question Archive

September 2023 Quick Question: Source of Hemolyzed Specimens

Our September 2023 Quick Question is a simple poll that we hope to use to describe means to reduce specimen hemolysis. If you don’t see an answer that fits your situation, please add your comment below.

Quick Question Archive

August 2023 Quick Question: Coag Specimen Hemolysis

Our August 2023 Quick Question asks, How do you distinguish ex vivo from intravascular plasma hemolysis? The question arises from our lengthy July 25, 2023 discussion, DIC and hemolysis, and is a poll; there is no wrong answer. Read the comments section featuring hemostasis experts Dave McGlasson, Dr. Emmanuel Favaloro, Dr. Giuseppe Lippi, and Robert […]

Quick Question Archive

July 2023 Quick Question Summary: Frozen Specimens

Our July 2023 Quick Question, How long may platelet-poor plasma be stored at –20°C? drew 52 respondents. Here are our results: 4 hours: 4 [8%] 24 hours: 4 [8%] 2 weeks: 21 [40%] 2 months: 15 [29%] 12 months: 8 [15%] This question arose in response to our lengthy June 15, 2023 post, Freezing Coagulation […]

Quick Question Archive

July 2023 Quick Question

Our July Quick Question asks, “How long may platelet-poor plasma be stored at –20 degrees C?” This reflects our recent series of posts regarding hemostasis specimen management, including our June 21 discussion on Specimen Transport. Many specimen management issues are up for review and will be reflected in a new edition of the CLSI Guideline […]

Quick Question Archive

June, 2023 Quick Question Review

Our June 2023 Quick Question asked, “Name the bispecific antibody-based FVIII inhibitor bypass agent.” Our 68 respondents answered… Caplacizumab [Cablivi]: 3 [4%] Eculizumab [Soliris]: 8 [12%] Emicizumab [Hemlibra]: 53 [78%] Eloctate: 3 [4%] Jivi: 1 [2%] Genentech’s emicizumab is the bispecific antibody that bypassed FVIII in to join FIX to FX, activating FX. Emicizumab is […]

Quick Question Archive

June 2023 Quick Question: Factor VIII Inhibitor Bypass

Our June Quick Question asks, “Name the bispecific antibody-based FVIII inhibitor bypass agent,” and lists several recently released therapeutics that are changing the shape of hemostasis disorder treatment. Please select your answer from the column on the right and add your comments below.

Quick Question Archive

May 2023 Quick Question: DTI

Our May 2023 Quick Question asks, “Which DOAC is a direct thrombin inhibitor? Our 70 respondents chose… Dabigatran [Pradaxa]: 56 [80%] Rivaroxaban [Xarelto]: 3 [4%] Apixaban [Eliquis]: 3 [4%] Warfarin [Coumadin]: 7 [10%] Clopidogrel [Plavix]: [2%] Dabigatran is the direct thrombin inhibitor, whereas rivaroxaban and apixaban are direct anti-Xa inhibitors. Clopidogrel is an antiplatelet antithrombotic. […]

Quick Question Archive

May 2023 Quick Question: DOACs

Our May 2023 Quick Question asks “Which DOAC is a direct thrombin inhibitor?” Please select your answer. If you would like to add a comment, please click Comments below.

Anticoagulant Therapy

April 2023 Quick Question: Prince Alexis

Our April 2023 Quick Question asked, “What was Russian Prince Alexis’s disorder? Our 41 participants chose: Hemophilia A [FVIII deficiency] 16 [39%] Hemophilia B [FIX deficiency] 15 [37%] Hemophilia C [FXI deficiency] 3 [7 %] Unknown 7 [17%] While the bodies of the Tsar, Tsarina, three daughters, and servants were exhumed in 1991, the remains […]

Bleeding Disorders

March 2023 Quick Question: Apixaban Reversal

Our March 2023 Quick Question asked, “Which reversal agent is effective in managing apixaban overdose?” Our 45 respondents chose: rFVIIa [NovoSeven]: 4 [9%] Andexanet alfa: 28 [62%] Idarucizumab: 5 [11%] Vitamin K: 6 [13%] FFP: 2 [5%] Before direct reversal agents became available, DOAC overdose-related bleeding was treated by attempting to absorb undigested anticoagulant from […]

Anticoagulant Therapy

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

Cheat Sheets from George

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