Sep 29 2025

george

October 2025 QQ: Reporting Assay Uncertainty Data

Please refer to our August 29, 2025 discussion, “Hemostasis Assay Statistical Variation.” In this post, we linked the article, Mullier F, Gouin-Thibault I, Meijer P, et al. Time to integrate measurement uncertainty in method comparison and interpretation of hemostasis laboratory assays. Res Practice Thromb Hemost 2025: 9, https://doi.org/10.1016/j.rpth.2025.102993. The authors contend that we should report uncertainty […]

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Quick Question Archive

Sep 29 2025

george

September 2025 QQ: Viscoelastometry Discussion

Our September 2025 Quick Question asked, “What viscoelastometry device is employed at your facility?” A modest group of thirteen participants answered… TEG 6s: 4 (31%) TEG 5000: 2 (15%) ROTEM: 5 (39%) Sonoclot: 0 Hemosonics Quantra: 2 (15%) The TEG 5000 was developed in 1948, and the Sonoclot in 1975; both represent the pioneering phase […]

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Quick Question Archive

Sep 1 2025

george

September 2025 QQ: Viscoelastometry

Our September 2025 QQ is a poll that asks, “What viscoelastometry device is employed at your facility?” Often, VET devices are employed in the OR or ER, both near-patient applications. For many years, we’ve used the time-honored Thromboelastograph (TEG) 5000 or its competitor, the Sonoclot, both of which are available worldwide. Newer offerings include the […]

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Quick Question Archive

Sep 1 2025

george

August 2025 QQ: Direct Oral Anticoagulants

Our August 2025 QQ is a poll that asked, “What AC does your provider prescribe for non-valvular AFIB?” Here are the choices made by our 18 responders: Apixaban (Eliquis) 10 (56%) Clopidogrel (Plavix) 0 Dabigatran (Pradaxa) 3 (16%) Rivaroxaban (Xarelto) 1 (6%) Warfarin (Coumadin) 4 (22%) This QQ arose from discussions with my (Geo) PCP […]

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Anticoagulant Therapy

Jul 30 2025

george

August 2025 QQ: Anticoagulant Choice for AFIB

Our August 2025 Quick Question asks, “What AC does your provider prescribe for non-valvular AFIB?” I (Geo) asked my PCP this question at my annual wellness visit on July 29, 2025. Not a personal concern, just curious. Please provide your answer on the right and add your comments, which will appear in our end-of-month summary.

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Quick Question Archive

Jul 29 2025

george

July 2025 QQ: Hemophilia Rebalancing Therapy

Our July 2025 Quick Question asked, “Which is a hemophilia ‘rebalancing’ therapeutic?” The question attracted a modest 22 participants, perhaps an indication that rebalancing therapy was only FDA-approved in 2025 and awaits approval in Canada and Europe. Here are your responses… Valoctocogene roxaparvovec-rvox (ROCTAVIAN) 3 (14%) Efanesoctocog alfa (ALTUVIIIO) 1 (4%) Emicizumab (HemLibra) 7 (32%) […]

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Quick Question Archive

Jul 1 2025

george

July 2025 Quick Question: Hemophilia Therapeutics

At the June 21–25 ISTH meeting in Washington, DC, we heard several quality presentations describing the new hemophilia treatment materials, including updated EHL concentrates plus the bypassing, rebalancing, and gene transfer therapies. In follow-up, our July 2025 Quick Question asks you to select the choice that represents the recently approved rebalancing therapies. Please make your […]

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Bleeding Disorders

Jun 30 2025

george

June 2025 Quick Question Summary: Fibrinolysis

Our June 2025 Quick Question was a quiz that asked, “Which fibrinolysis component directly digests fibrin?” Our 51 respondents answered… Plasminogen: 12 (23%) Antiplasmin: 0 D-dimer: 1 (2%) Plasmin: 37 (73%) TPA: 1 (2%) The correct answer is #4, plasmin. In brief, plasminogen is a zymogen. Plasmin, the activated form of plasminogen, binds and digests […]

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Fibrinolysis

May 30 2025

george

June 2025 Quick Question: Fibrinolysis

Our June 2025 Quick Question asks, Which fibrinolysis component directly digests fibrin? Please find the question on the right side of the “Posts” menu and make your selection. As always, we invite your comments using the function below.

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Quick Question Archive

May 30 2025

george

May 2025 QQ Summary: Terminology

Our May 2025 Quick Question was meant to be a brain teaser inspired by Dave McGlasson’s December 2023 Clot Club entry, “Do We Need to Standardize Coagulation Nomenclature in Today’s Laboratory Environment?” The question listed several assays that use the letter C.  “Which is the routine assay for inflammation?” It seems that only four of […]

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Quick Question Archive