Quick Question Archive

June 2024 QQ Poll Summary: OSA and Chromogenics

Our June 2024 Quick Question attracted 18 responses. This month’s Question was a poll that asked, “How do you assay factor concentrates?” Here are our answers: Clot-based assay: 11 [61%] Chromogenic substrate assay: 4 [22%] Other: 3 [17%] Factor assays are most often requested to monitor hemophilia factor concentrate activity for patient-specific efficacy and the […]

June 2024 QQ: Factor Assays

Our June 2025 Quick Question is a poll that asks, “How do you assay factor concentrates?” The question reflects the current hemostasis laboratory efforts to quantify therapeutic FVIII or FIX concentrate activity given the variety of plasma-based, recombinant, B-domain-deleted, and extended half-life therapeutics. We also manage factor concentrates that are employed to control breakthrough bleeds […]

Quick Question Archive

May 2024 QQ Summary: Platelet Transfusion Trigger

Our May 2024 Quick Question was a survey that asked, “Below what PLT count limit do you provide PLT concentrate?” our 25 participants answered as follows: <150,000/uL: 2 [8%] <50,000/uL: 3 [12%] <20,000/uL: 7 [28%] <10,000/uL: 13 [52%] <5,000/uL: 0 The correct answer is “it depends.” Current WHO platelet concentrate transfusion guidelines are available at […]

Quick Question Archive

May 2024: QQ Poll: Trigger Point for PLT Concentrate Therapy

Our May 2024 Quick Question asks, “Below what PLT count limit do you provide PLT concentrate?” Please show us your facility’s PLT count limit and add a comment below or using the Questions or Comments box.

Bleeding Disorders

April 2024 QQ Summary: MYH9 Mutation

Our April 2024 Quick Question, “What PLT production abnormality is an MYH9 gene mutation?” attracted 26 responses. Here’s the distribution: Thrombocytopenia with absent radii [TAR]: 4 [15%] Bernard-Soulier syndrome [BSS]: 2 [7%] Immune thrombocytopenia [ITP]: 1 [4%] Wiskott-Aldrich syndrome: 1 [4%] May-Hegglin disorder: 18 [70%] The production abnormalities are associated with mild to severe bleeding. […]

Bleeding Disorders

April 2024 QQ: MYH9 Mutation

Molecular diagnostic methods have defined scores of platelet disorders that by phenotype alone were categorized as production or functional disorders. Our April 2024 Quick Question is a quiz that “scratches the surface” by asking what disorder or syndrome is part of the MYH9 gene mutation family. For a look at molecular diagnostics practical applications, see […]

Platelet Function Testing

March 2024 Quick Question Summary: Factor Deficiency

Our March 2024 Quick Question was a quiz. The question was, “What factor deficiency causes bleeding but doesn’t prolong the PT or PTT?” Our 75 respondents answered as follows: FVIII: 7 [9%] FIX: 3 [4%] FXI: 3 [4%] FXII: 8 [11%] FXIII: 54 [72%] Factor VIII, IX, XI, and XII deficiencies prolong the PTT but […]

Bleeding Disorders

March 2024 Quick Question: Factor Deficiency

Our March 2024 Quick Question, a factor deficiency quiz asks “What factor deficiency causes bleeding but doesn’t prolong the PT or PTT?” Please select the one correct answer and make additional comments below.

Bleeding Disorders

February 2024 QQ Summary: Rosenthal Syndrome

Forty-two participants answered our February 2024 Quick Question, “What factor deficiency is named Rosenthal syndrome?” Here are the answers: FV: 3 [7%] FVII: 2 [5%] FX: 2 [5%] FXI: 28 [67%] FXII: 5 [11%] FXIII: 2 [5%] Most of us correctly chose factor XI deficiency, Rosenthal Syndrome. FXI deficiency is an autosomal recessive hemophilia with […]

Bleeding Disorders

Feb 2024 Quick Question: Rosenthal Syndrome

Our February 2024 Quick Question is a quiz that tests the knowledge we gained in our entry-level coagulation courses. At the end of February, we’ll use this as a means to discuss the efficacy of currently available DOACs and some new developments.

Coagulation Factors

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

Cheat Sheets from George

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