More on Low Factor X, Normal PTT

Here is a follow-up comment from Dr. Larry Brace, Edward Hospital, Naperville, IL. With regards to the patient with pubertal menorrhagia, has anyone tested the parents? If this is an inherited X deficiency, both parents would need to be heterozygous in order to have a child that has 1% factor X. If both parents have normal X […]

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May 25 2011

george

Changing Reagent Lots

From Cathy Labare: We are changing reagent lot numbers for our PTs and PTTs. How close should the normal ranges of the new lot be to the current normal range? Hi, Cathy, thank you for your question. We use a limit of 10%, meaning if the normal range (reference interval) limits from the new lot […]

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Changing Reagent Lots

From Cathy Labare: We are changing reagent lot numbers for our PTs and PTTs. How close should the normal ranges of the new lot be to the current normal range? Hi, Cathy, thank you for your question. We use a limit of 10%, meaning if the normal range (reference interval) limits from the new lot […]

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Consumptive Coagulopathy

From “Sunny:” Disseminated intravascular coagulation (DIC) and consumptive coagulopathy are used interchangeably. My question is, are they actually the same? Hello, Sunny. Yes these are simply synonyms for the same disorder. The term consumptive coagulopathy reflects the diminished coagulation factor activity typical of the condition, whereas DIC describes formation of microthrombi in capillaries and organs.

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Low Factor X, Normal PTT

From Vilas Hiremath, United Labs: I have a patient with puberty menorrhagia. Her prothrombin time (PT) is prolonged, but corrected with normal pooled plasma (NPP). Her partial thromboplastin (PTT), thrombin time (TT), fibrinogen, FVII, and FV are all normal and her thromboelastography (TEG) R-value is prolonged to 60 minutes. Her factor X assay result is < […]

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Prothrombinase-Induced Clotting Test

I need your help. I have only a brief acquaintance with CenterChem’s Pefakit prothrombinase-induced clotting test (PiCT). Samama MM, Guinet C, Laboratory assessment of new anticoagulants. Clin Chem Lab Med 2011;49:761–72 supports the PiCT for monitoring fondaparinux, dabigatran, and rivaroxaban (with minor modifications). The PiCT has been available for at least ten years for monitoring standard unfractionated […]

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Elevated VWF Linked to Mortality in AF Patients

A recent JACC publication establishes a link between VWF plasma concentrations and adverse thrombotic and bleeding events in anticoagulated atrial fibrillation patients. See Roldán V, Marín F, Muiña B, Torregrosa JM, Hernández-Romero D, Mariano Valdés M, Vicente V, and Lip GYH. Plasma von Willebrand factor levels are an independent risk factor for adverse events Including mortality […]

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PT Ratio?

There’s been a lively discussion in the comments section attached to a September 18, 2008 post entitled

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Mayo Clinical Resources Site

I maintain an Additional Hemostasis Sites page on Fritsma Factor to direct you to coagulation information from many sources. I just added an informative interactive site called Mayo Clinical Resources which provides information in all laboratory disciplines, not just hemostasis. Type in a topic and it immediately returns everything Mayo Medical Laboratories has published. Give it a try. Geo.

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DTIs and the Fibrinogen Assay

From “Gagee:” Do you know if Dabigatran affects the fibrinogen levels like the other DTIs, argatroban, bivalirudin and lepirudin? Hello. Yes, but it isn’t so much that the DTIs affect the fibrinogen level, it is that they prolong the thrombin time, upon which the Clauss fibrinogen assay is based, giving the illusion of reduced fibrinogen. […]

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More on Low Factor X, Normal PTT

Changing Reagent Lots

Changing Reagent Lots

Consumptive Coagulopathy

Low Factor X, Normal PTT

Prothrombinase-Induced Clotting Test

Elevated VWF Linked to Mortality in AF Patients

PT Ratio?

Mayo Clinical Resources Site

DTIs and the Fibrinogen Assay

George Fritsma MS MLS

Cheat Sheets from George

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