Instrumentation

FDA Registration

I’m posting this message at the request of a colleague. “George, I’m told by one of my suppliers that their products are US FDA registered. Does this mean the FDA endorses the company and its products?” Thank you for your question. FDA terminology may sometimes be complex and has perhaps confused your supplier’s representative. The […]

Instrumentation

Yet More on Promacta

This is from friend and colleague, Dean Willett, Instrumentation Laboratory: Hi, George; A few points to consider… There are two potential sources of interference here: biochemical and optical. Much like hemolysis, if the sample contains biochemical interference, results will be affected regardless of detection method. In the absence of any data it’s not clear if this drug […]

Bleeding Disorders

More on Promacta

From my friend Ali Sadeghi-Khomami, PhD, Precision Biologic Inc: Eltrombopag is a diazo derived compound that acts like pH indicators, i. e., it changes colour at different concentrations of hydronium ions. Thus it is expected that it interferes with chromogenic assays such as the bilirubin assay, especially when assay calibration will not match the colour of the testing sample. […]

Bleeding Disorders

Resource to Compare Analyzers

From Stephanie Morgan: We are comparing analyzers that perform factor assays, platelet studies, thrombosis testing, and other specialty testing while remaining cost efficient. Where would be the best resource to compare analyzers in each category? Thank you. Hello, Stephanie, and thank you for your question. Your best resource is the College of American Pathologists’ CAP Today Product […]

Instrumentation

More On Optical Versus Mechanical Clot Detection

In follow-up to Click here for the article: Cunningham et al 2012.

Instrumentation

Coag Tests for a Community Hospital

From Meg Harlin, Peninsula Regional Medical Center in Maryland: Our Laboratory will be bringing in new coagulation analyzers from Instrumentation Laboratories, Inc.; TOPS 300, in February, 2014. We currently perform prothrombin time and international normalized ratio (PT/ INR), partial thromboplastin time (APTT, PTT), fibrinogen, and D-dimer. A Few years ago we stopped doing bleeding times, mixing studies and […]

Anticoagulant Therapy

FVIII Inhibitor Assays

From Saravanan Vinayagam: We are trying to set up the factor VIII inhibitor assay on our ACL TOP analysers. Has anyone got an SOP or previous experience in validating inhibitor assay in an automated analysers? Thank you. Hello, Saravanan Vinayagam, and thank you for your post. I’m hoping that an IL technical representative will see this […]

Bleeding Disorders

Correlating ACT from the i-STAT and Hemochron

A message from Sue Allen at Baptist Hospital: George, a while back you posted aquestion to the masses about the correlation between the Abbott i-STAT ACT versus the ITC Hemochron 401 and the Hemochron Jr. and I was wondering if you ever received any responses and have any further information on the subject. We are currently doing the same conversion and […]

Anticoagulant Therapy

Participant Poll: Who Uses TEG?

From Kim Kinney at Indiana University Medical Center (IU Health): Hi George. We are being asked to make the thromboelastograph (TEG) available in our special coag lab for clinical use. I am curious to poll others regarding the use of TEG, who is running the test, who is interpreting the results, etc. We have had the TEG available […]

Global Hemostasis Assays

Dabigatran and the iSTAT

From “SwimRose:” Hi George, We recently had a case in our ER of a stroke patient on Pradaxa giving an INR of 2.0 with ISTAT, but the main lab instrument, an IL ACL, gave 1.1. Please comment. Hello, and thank you for your question, which drove me to an early-morning search of theAbbott Diagnostics site for […]

Anticoagulant Therapy

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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