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Coagulation Factors

Nov 12 2025
george

Alternate Functions of AT, PC, PS, and TFPI

Go to your medical library to download the meta-analysis Prouse T, Mast AE, Ignjatovic V, Kovac M, Bereczky Z, Majumder R. Alternate functions of physiological anticoagulants. J Thromb Haemost. 2025:S1538-7836(25)00540-9. doi: 10.1016/j.jtha.2025.08.014. PMID: 40907701. Abstract The anticoagulant proteins antithrombin, protein C, protein S, and tissue factor pathway inhibitor are physiological regulators of the blood coagulation […]
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Thrombophilia
Oct 29 2025
george

PT and PTT Illustrated Mechanisms

For an illustrated overview of the hemostasis mechanisms associated with the PT and PTT, obtain this article from your medical library: Harris NS, Marin MJ, Butenas S. Beyond prothrombin time and activated partial thromboplastin time: coagulation in vivo-an illustrated review. Lab Med. 2025;56:438–47. doi: 10.1093/labmed/lmae125. PMID: 40319459. Abstract The steps that initiate coagulation in vivo […]
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Coagulation Factors
Oct 28 2025
george

November 2025 QQ: Stuart-Prower Factor

Our November 2025 Quick Question tests our historical knowledge. Not long ago, we learned about various names for the coagulation factors; e. g., proaccelerin, proconvertin, and plasma thromboplastin antecedent. Some factor names were proper nouns, for example, Hageman factor, Fletcher factor, and Fitzgerald factor. This month’s question asks you to identify the Stuart-Prower factor by […]
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Quick Question Archive
Sep 12 2025
george

Cell-based Coagulation Overview

Check your medical library to read Harris NS, Marin MJ, Butenas S. Beyond prothrombin time and activated partial thromboplastin time: coagulation in vivo-an illustrated review. Lab Med. 2025;56:438–47. doi: 10.1093/labmed/lmae125. PMID: 40319459. Here’s the abstract: The steps that initiate coagulation in vivo are different from the components of prothrombin time (PT) and activated partial thromboplastin time […]
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Coagulation Factors
Jun 20 2025
george

Lab Assessment of FVIII Inhibitors

Click here for an open-access article describing the need for factor inhibitor assessment: Favaloro EJ, Curnow J, Pasalic L. Laboratory assessment of factor VIII inhibitors: when is it required? A perspective informed by local practice. J Clin Med. 2024;14:13. doi: 10.3390/jcm14010013. PMID: 39797095; PMCID: PMC11720995. See also our factor inhibitor discussions under the Bleeding Disorders heading.
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Bleeding Disorders
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George Fritsma MS MLS

George Fritsma is a medical laboratory scientist, educator, and author. George  is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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What VWD subtype Is caused by a VWF gain of function?