Chilling The NBA Reaction Mixture

From Dr. Mirta Arias: Dear George, Thank you for your answer in the blog. I have another question. Dr. Robinson in ISLH argued that it is good to chill the post 2 hour/37°C 37 incubation mixtures of patient + pool normal plasma, and control at 2–8°C for 10 minutes and then measure the factor VIII. In […]

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Bleeding Disorders

Aug 28 2016

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Nijmegen Bethesda Assay

From Dr. Mirta Arias, Dear George, which is the procedure for determining the cut-off of Bethesda method and Nijmegen? Is there any Excel spreadsheet to perform it? Do you use only normal or normal and patients? Thanks, Mirta Hello, Dr. Arias, and thank you for your question. For a comprehensive answer, I turned to Amanda […]

Bleeding Disorders

CLMA Alabama Chapter Meets August 16

The Alabama Chapter of the Clinical Laboratory Management Association hosts an all-day meeting Tuesday, August 16, 2016 at the Bradley Center of Children’s Hospital of Alabama. George will speak at 10:35–11:45 on “Hemophilia Therapy Management, From Rasputin to Recombinants.” His presentation includes description of the new extended half-life factor concentrates, antithrombin suppression therapy, and gene […]

Bleeding Disorders

Nijmegen-Bethesda Assay Method

Sarah Payne and Kerri Klemm request information on how to perform the CDC modification of the Nijmegen-Bethesda Assay for coagulation factor inhibitors. Thank both of you for your request, which provides George the opportunity for self-promotion. Please tap or click Coagulation Factor Inhibitors and the Nijmegen Bethesda Assay, a recording of my June 2 digital […]

Bleeding Disorders

Undergrad Hemostasis Education

This June 29, 2016 note was posted by Patricia Boyer, MS, MLS, Program Director, Zablocki VAMC School of Medical Technology to the American Society for Clinical Laboratory Science educators bulletin board: I am working on my hemostasis curriculum, and I was wondering how many instructors teach coagulation using the multicomponent complexes–specifically the tenase and prothrombinase complexes concepts. This is my second year […]

Arterial Thrombosis

LABCON Presentation: Coagulation Factor Inhibitors

Hi, this is George writing from LABCON 2016 in beautiful Charlottetown, Prince Edward Island. Tomorrow, Friday, June 16, I will present “Identifying, Measuring, and Treating Coagulation Factor Inhibitors,” sponsored by Precision BioLogic Inc, of Dartmouth, Nova Scotia. I made a few updates to the lecture today, so there are three slides that are not in […]

Bleeding Disorders

Correcting for Hypothermia

From Carla Purvis, MT (ASCP) SH, Parkview Regional Medical Center in Fort Wayne: Hi, George. We have acute care clinicians requesting temperature correction for prothrombin time results for patients who have clinically induced hypothermia. CAP standards state prothrombin times must be performed at 37C. Do you have any references for performing temperature corrections? Thanks. Hi, […]

Bleeding Disorders

New Quick Question: Bethesda Titers

Please review and vote on our May, 2016 Quick Question, “How does your laboratory measure factor inhibitors?” in preparation for our Thursday, June 2 Webinar described below. George will report on your Quick Question findings. If none of the answers reflect your policy, please add a comment to this entry. Please join Precision BioLogic Inc, […]

Bleeding Disorders

Trauma-induced Coagulopathy Presentation

Thanks to Melissa Doumolin, Sonja Nehr-Kanet, and everyone in Boise who made my visit to Idaho memorable. Thanks also to those who participated in the presentation, “Trauma-induced Coagulopathy and Massive Transfusion Protocol.” I’ve attached my handouts in 1-per-page and 6-per-page format; the former if you want to see it on your phone or tablet, the […]

Bleeding Disorders

Factor V Antigen Assay?

From Heather DeVries, Indiana University. Hello George! We have a physician requesting a factor V antigen assay. I have not been able to find it anywhere. Do you know if there is an assay for this? If so, who performs it? Thanks! Heather. Hi, Heather. I checked the usual specialty reference labs and the companies […]

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Bleeding Disorders

Bleeding Disorders

Chilling The NBA Reaction Mixture

Nijmegen Bethesda Assay

CLMA Alabama Chapter Meets August 16

Nijmegen-Bethesda Assay Method

Undergrad Hemostasis Education

LABCON Presentation: Coagulation Factor Inhibitors

Correcting for Hypothermia

New Quick Question: Bethesda Titers

Trauma-induced Coagulopathy Presentation

Factor V Antigen Assay?

George Fritsma MS MLS

Cheat Sheets from George

Questions or Comments?

Quick Question