Bleeding Disorders

July, 2019 QQ: Managing Trauma

Our July, 2019 Quick Question was directed to trauma centers, and attracted 22 responses. The question was… How does your institution manage trauma-induced coagulopathy? Crystalloid plasma expanders 3 (14%) pRBCs 2 (9%) 1:1:1 components 12 (54%) Whole blood 2 (9%) Tranexamic acid 3 (14%) Thank you for your answers. Arising from military experience, a handful […]

Bleeding Disorders

Therapeutic Reptilase

Ning Tang writes, Dear George, In China, a categary of hemostatic agents from snake venom named “Haemocoagulase” are widely used, basically they are the generic drugs of Reptilase®, which is produced by a Swiss company. We find that intravenous injection of this drug can cause severe hyperfibrinolysis and hypofibrinogenemia. It seems that Reptilase has been […]

Bleeding Disorders

Vitamin K Kinetics

George received a series of questions about vitamin K kinetics from colleague and friend Catherine N. Otto, MLS, PhD, Rutgers University. Dr. Otto is assisting a Nutrition Science colleague. It seems that vitamin K deficiency (as defined by PT/INR) does not show up until there is serious depletion in the amounts of these activated proteins. Why? […]

Anticoagulant Therapy

Case: VWD? Please Answer

A 16-year-old girl experiences chronic menorrhagia. Her PT is 12.2 s, PTT 37.1 s (H), factor VIII activity 51% (L), VWFag 54%, VWFactivity 45% (L), VWFRCo 43% (L), VWF multimers: normal distribution. CBC results are normal except HGB is 11.8 g/dL (L). What is her presumptive diagnosis, what follow-up testing, if any, is necessary, and […]

Bleeding Disorders

May 15 Inhibitors Webinar

It’s not too late to register for Precision BioLogic’s May 15 webinar, “Update on FVIII Inhibitor Testing and Introduction to the CRYOcheck™ Factor VIII Inhibitor Kit,” by CDC‘s Connie H. Miller, PhD. The live webinar goes from 2–3 Wednesday afternoon.

Bleeding Disorders

77-YO Female Systemic Bleeding

George heard from a colleague who is looking for support on a provocative case. A 77-year old woman is experiencing systemic bleeding. Key laboratory findings: von Willebrand factor antigen: 200% von Willebrand factor activity by ristocetin cofactor: 100% Whole blood lumiaggregometry: no secretion (ATP release) to thrombin, ADP, collagen or arachidonic acid Could this be […]

Bleeding Disorders

Hemophilia Review Articles

Two excellent review articles appear in the March entry of the online journal, Clinical Laboratory Science. They are: Smith LJ, Castellone DD, Nardi MA. Hemophilia: Where are we today? Clin Lab Sci 2019, ascls.118.001271; DOI: https://doi.org/10.29074/ascls.118.001271, and Smith LJ. Hemophilia. Clin Lab Sci 2019; ascls.118.001289; DOI: https://doi.org/10.29074/ascls.118.001289

Bleeding Disorders

PBI FVIII Inhibitor Kit Approved

On March 13, 2019, Precision BioLogic Inc. announced US FDA clearance for the new CRYOcheck Factor VIII Inhibitor Kit. Click or tap here for the complete news release. This clearance follows approvals received from regulatory authorities in Canada, the European Union, Australia, and New Zealand, where the kit launched in February of this year. The […]

Bleeding Disorders

Quick Question: 41 YO Man With GI Bleeding Response

Our February, 2019 Quick Question was a case study entitled, “41-YO Man with GI Bleeding” (click or tap to review). For 56 responders, the answers and tallies were… Vitamin K deficiency 9% (5) Moderate liver disease 57% (32) Functional platelet disorder 4% (2) Disseminated intravascular coagulation 21% (12) Other: please provide a written response 9% […]

Bleeding Disorders

New FVIII Inhibitor Assay

An exciting news release from Precision BioLogic Inc. Today, we are announcing the availability of our new CRYOcheck Factor VIII Inhibitor Kit in Canada, the European Union, Australia, and New Zealand following market authorization by Health Canada and respective in-country regulatory authorities in January. Click here for full information about the CRYOcheck Factor VIII Inhibitor […]

Bleeding Disorders

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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