Bleeding Disorders

WFH Guidelines: Third Edition

On August 4, 2020 the World Federation of Hemophilia announced the publication of the WFH Guidelines for the Management of Hemophilia, 3rd edition, 2020 [click for the publication]. The guidelines were developed by a team of experts from around the world and have been updated to reflect important developments in the management of hemophilia since […]

Bleeding Disorders

Chromogenic Factor VIII Assay FDA-Cleared

On Monday, July 20, Fritsma Factor sponsor Precision BioLogic Inc. announced US FDA 510[k] clearance of their CRYOcheck™ Chromogenic Factor VIII assay. The assay had been previously approved in Canada, the European Union, Australia, and New Zealand. The assay boasts a test range from 0–200% FVIII using one standard curve and a limit of quantitation […]

Bleeding Disorders

April, 2020 Quick Question: HEMLIBRA Results

Our April, 2020 Quick Question was: “How does your facility measure factor VIII during HEMLIBRA therapy?” Here are our answers from 29 respondents: a. One-stage PTT-based FVIII assay: 17% (5) b. Two-stage chromogenic FVIII assay: 45% (13) c. PTT-based assay calibrated to emicizumab: 10% (3) d. There is no reliable assay: 28% (8) Dr. Ali […]

Bleeding Disorders

World Hemophilia Day

Today, April 23, 2020 is World Hemophilia Day. Click or tap here and visit the World Federation of Hemophilia site, where you find in-depth information and a webinar featuring care for hemophiliacs in the face of Covid-19. Our sponsor, Precision BioLogic Inc. is an annual WHD sponsor.

Bleeding Disorders

WFH: COVID and Bleeding April 9

Again with thanks to Elaine Benoit, Precision BioLogic Inc, for the following information, the World Federation of Hemophilia presents a webinar on Bleeding Disorders and Covid-19 [Click or Tap] Thursday, April 9 at 10 AM EDT.

Bleeding Disorders

April, 2020 Quick Question: HEMLIBRA

With the rapid onset of game-changing injectable emicizumab [HEMLIBRA] therapy for hemophilia, coagulation laboratories face a new challenge. On the occasions when HEMLIBRA-treated hemophiliacs need factor VIII concentrate therapy, or if there is a desire to test for residual factor VIII, what means does the laboratory possess? Likewise, the clinician may need a means to […]

Bleeding Disorders

March 2020 Quick Question Summary

Our March, 2020 Quick Question, “How does your facility measure extended half-life factor VIII concentrate therapy?” drew 24 votes, reflecting the number of laboratories serving Hemophilia and Bleeding Disorders services worldwide. Here are the answers: A. One-stage clot-based FVIII assay 46% [11] B. Two-stage chromogenic FVIII assay 42% [10] C. We don’t measure, assays are […]

Bleeding Disorders

EHL Factor IX Assays

Today, March 23, 2020, the International Journal of Laboratory Hematology released a study describing the clinical efficacy attributes of PTT-based one-stage clotting assays and two-stage chromogenic assays for the extended half-life factor IX concentrate, Alprolix. Click or tap the citation for the open-access article. Thank you to Dr. Ali Sadeghi-Khomami, Precision BioLogic Inc. for the […]

Bleeding Disorders

DIC in COVID-19 Pneumonia

Here is a JTH free-access brief report that illustrates mortality-related DIC parameters in coronavirus pneumonia, hinting at potential interventional therapy. Tang N, Dengju L, Wang X, Son Z. Brief Report: Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemostas 2020. DOI: 10.1111/jth.14768

Bleeding Disorders

VWD and Aspirin

An acquaintance’s daughter has type 1 von Willebrand disease. Her OB physician recommends a daily baby aspirin during her pregancy. Are there any circumstances in which aspirin is indicated during pregnancy in a woman with VWD? Please provide your opinion in our Comments section below or email to [email protected]. Thank you.

Antiplatelet Therapy

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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