Bleeding Disorders

Interpreting Inhibitor Mixing Study in a Hemophilia A Patient

I [Geo] received a physician’s question on 1-31-24: Dear Sir, Hope you are doing well. Thank you for creating this platform and sharing valuable resources with the world. We present a case of Hemophilia A with recent retroperitoneal hematoma and multiple transfusions–PRBC, FFP, Factor VIII, and NovoSeven. APTT of Test Plasma: 47 seconds [RI 22.2–33.1 […]

Please Provide Comments: Prolonged PT and PTT, Retinal Bleed

I’m [Geo] seeking comments about this case of a 65-YOA female on no anticoagulant with retinal hemorrhage and no other bleeding symptoms: Coag 1/18/24 1/19/24 1/20/24 1/21/24 PT 16.9 15.6 PTT 53 44 TCT 17 FG 592 576 FII 83 FV 79 FVIII 167 FIX 71 FX 75 FXI 80 VWF:Ag 121 VWF:RCo 147 D-dimer […]

Bleeding Disorders

WFH Statement on Cryoprecipitate

The World Federation of Hemophilia [WFH] is deeply concerned by the inclusion of pathogen-reduced and non-pathogen-reduced cryoprecipitate in the World Health Organization’s 23rd Essential Medicines List [EML] and Essential Medicines List for Children [EMLC]. Click here for the 12-23-23 WFH statement.

Bleeding Disorders

January 2024 Quick Question: Platelet Function Tests

Our January 2024 question is a poll submitted by Dave McGlasson, asking, “What platelet function test do you use?” While light transmittance aggregometry [LTA] has been available since the mid-1960s and is regarded by many as the reference method for platelet function testing, many have switched to the simpler whole blood aggregometry [WBA]. Our answers […]

Bleeding Disorders

December 2023 Quick Question Summary: VWD Subtype 2B

Our December 2024 Quick Question, “How do you test for VWD subtype 2B?” attracted 31 responses as follows: RIPA: 15 [48%] VWFAg: 2 [7%] VWF:CB: 5 [16%] VWF:RCo: 6 [19%] Multimeric analysis: 3 [10%] Our question drew this comprehensive discussion from Dr. Emmanuel Favaloro on Tuesday, December 12, 2023: Hi George, I have been following […]

Bleeding Disorders

FVII Deficiency

I [Geo] received this post on Monday, December 18: Hi George, I have a few questions that I was hoping you could help me with. I’m a patient with factor 7 deficiency and have a background in nursing. I was diagnosed at 49% but have had issues with fluctuations in percentages between standalone labs and […]

Bleeding Disorders

Acquired Hemophilia, rpVIII, and Bethesda Titer

Here is a 12-2-23 email from Hrvoje Melinšćak MD, Consultant in Haematology, the Warren Alpert Medical School of Brown University, Rhode Island Hospital/The Miriam Hospital. I would enquire regarding rpFVIII’s impact on inhibitor titre assessment through the Bethesda assay in a case regarding acquired haemophilia A. Does significant background rpFVIII (Obizur) concentrate lend to significant […]

Bleeding Disorders

Trauma-induced Coagulopathy Conversation Part 3

Part 3 of my Coag Conversation with Dr. Maureane Hoffman entitled Trauma-induced Coagulopathy; The Laboratory’s Role in Care, is now available from the BioMedica Diagnostics website.

Bleeding Disorders

December 2023 Quick Question: VWD Subtype 2B

Our December 2023 Quick Question asks, “How do you test for VWD subtype 2B?” This is in follow-up to our February 2023 question, “What VWF activity assay do you use?” VWD subtype 2B is a qualitative VWF deficiency caused by a gain-of-function mutation that increases VWF-platelet-binding avidity. Please answer the quiz and post your comments […]

Bleeding Disorders

Recombinant ADAMTS13 Therapeutic

On November 9, 2023, Takeda’s recombinant ADAMTS13 received FDA approval for the care of congenital thrombotic thrombocytopenic purpura [cTTP]. Click here for their news release. Click here for the US Thrombotic Microangiopathy Alliance for more cTTP information and information on the family of TMAs.

Bleeding Disorders

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

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