Bleeding Disorders

July 2026 QQ: VWD Therapeutic

We commemorate the 1926 publication by Finnish physician, Eric von Willebrand, Von Willebrand, E A (1926). “Hereditär pseudohemofili”. Finska Läkaresällskapets Handlingar (in Swedish). 68: 87–112. Dr. von Willebrand’s title, “Hereditary Pseudohemophilia,” was updated to our current name, von Willebrand disease, in the late 1930s, and the responsible protein was named von Willebrand factor in 1971. […]

Bleeding Disorders

June 2026 QQ Review: VWF Gain of Function

Our June 2026 QQ, which drew 30 responses, asked, “What VWD subtype is caused by a VWF gain of function?” Here are your responses: VWD type 1: 3 (10%) VWD subtype 2A: 1 (3%) VWD subtype 2B: 24 (80%) VWD subtype 2M: 2 (7%) VWD subtype 2N: 0 VWD type 1 is the quantitative form […]

Bleeding Disorders

A New Era in VWD Treatment

Click here for an informative LinkedIn/Hemostasis Today post from Shadi Tabibian, Deputy of Research at Blood Diseases Research Centers in Iran University of Medical Sciences, A New Era in VWD Treatment. For decades, the management of VWD has relied mainly on VWF concentrates, desmopressin, antifibrinolytic agents, and hormonal therapies. Although these treatments remain effective for […]

Bleeding Disorders

Review: Diagnosis and Management of Hemophilia A & B

Click here for an open-access review: Lim MY, Ardila J, Castaman G, et al. Diagnosis and management of hemophilia A and B. J Thromb Haemost. 2026;24:2341–54. doi: 10.1016/j.jtha.2026.04.005. PMID: 41967712. Abstract Hemophilia A and hemophilia B are inherited bleeding disorders caused by a deficiency or absence of coagulation factor FVIII and FIX, respectively. The severity […]

Bleeding Disorders

Coag Conversation: 100 Years of Von Willebrand Disease and Upcoming Advances

Click here for the first of our three-part Coag Conversation series, 100 Years of von Willebrand disease. featuring George Fritsma interviewing Robert Sidonio, MD. Dr. Sidonio is the Medical Director of the Clinical Research Office at the Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta and is the Professor of Pediatrics, Emory […]

Bleeding Disorders

Emergency Hemorrhage Hemostasis Profile

Cristina Figueroa Villalba, MD, authored a provocative editorial, When minutes matter: the laboratory’s role in rapid hemostasis assessment in the May/June issue of CLN, a publication of ADLM. Please review this 10-minute read and respond with your recommendations for a rapid-test profile for acute hemorrhage. For instance, would you include a PTT, the DOASENSE® urinary […]

Bleeding Disorders

Factor XIII and Clot Stability

Click here for an open-access illustrated discussion via Hemostasis Today by Abdul Mannan of the multiple roles of FXIII and the adverse effects of FXIII deficiency related to wound healing and clot integrity.

June 2026 QQ: VWF Gain of Function

In keeping with our “100 Years of VWD” theme, our June 2026 Quick Question, which appears in the right-hand column, asks, “What VWD subtype is caused by a VWF gain of function?” Gain of function refers to VWF with enhanced binding avidity to the platelet GP1b binding site. For assistance, navigate to our Informative Module, […]

Quick Question Archive

“Covid Coag”

On May 26, I (Geo) posted a link to our informational module, The Cell-based Coagulation Model. On May 15, I posted a link to our Coagulation Overview Module. The third in a series of “Mechanism” modules, and perhaps the most complex, is entitled Covid Coag. Though thanks to vaccination technology, we think less today about […]

Bleeding Disorders

A Treasure Trove of VWD Articles

The May 2026 issue of Seminars in Thrombosis and Hemostasis provides a “mother lode” of open-access VWD articles in observance of Dr. Erik von Willebrand‘s 1926 article, Hereditar Pseudohaemophili, now 100 YOA. Check with your medical library for Nilsson IM. Commentary to Erik von Willebrand’s original paper in Haemophilia. 1999;5:220-1. doi: 10.1046/j.1365-2516.1999.0320a.x. PMID: 10444292 (no […]

Bleeding Disorders

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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