Bleeding Disorders

WFH: COVID and Bleeding April 9

Again with thanks to Elaine Benoit, Precision BioLogic Inc, for the following information, the World Federation of Hemophilia presents a webinar on Bleeding Disorders and Covid-19 [Click or Tap] Thursday, April 9 at 10 AM EDT.

Bleeding Disorders

April, 2020 Quick Question: HEMLIBRA

With the rapid onset of game-changing injectable emicizumab [HEMLIBRA] therapy for hemophilia, coagulation laboratories face a new challenge. On the occasions when HEMLIBRA-treated hemophiliacs need factor VIII concentrate therapy, or if there is a desire to test for residual factor VIII, what means does the laboratory possess? Likewise, the clinician may need a means to […]

Bleeding Disorders

March 2020 Quick Question Summary

Our March, 2020 Quick Question, “How does your facility measure extended half-life factor VIII concentrate therapy?” drew 24 votes, reflecting the number of laboratories serving Hemophilia and Bleeding Disorders services worldwide. Here are the answers: A. One-stage clot-based FVIII assay 46% [11] B. Two-stage chromogenic FVIII assay 42% [10] C. We don’t measure, assays are […]

Bleeding Disorders

EHL Factor IX Assays

Today, March 23, 2020, the International Journal of Laboratory Hematology released a study describing the clinical efficacy attributes of PTT-based one-stage clotting assays and two-stage chromogenic assays for the extended half-life factor IX concentrate, Alprolix. Click or tap the citation for the open-access article. Thank you to Dr. Ali Sadeghi-Khomami, Precision BioLogic Inc. for the […]

Bleeding Disorders

DIC in COVID-19 Pneumonia

Here is a JTH free-access brief report that illustrates mortality-related DIC parameters in coronavirus pneumonia, hinting at potential interventional therapy. Tang N, Dengju L, Wang X, Son Z. Brief Report: Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemostas 2020. DOI: 10.1111/jth.14768

Bleeding Disorders

VWD and Aspirin

An acquaintance’s daughter has type 1 von Willebrand disease. Her OB physician recommends a daily baby aspirin during her pregancy. Are there any circumstances in which aspirin is indicated during pregnancy in a woman with VWD? Please provide your opinion in our Comments section below or email to [email protected]. Thank you.

Antiplatelet Therapy

Emicizumab

George had the opportunity to speak with two UAB Hematology-Oncology fellows who work with the Hemophilia and Bleeding Disorders service at Children’s Hospital of Alabama. They report that the center’s move to hemophilia A therapy using emicizumab (HEMLIBRA) has significantly changed the lives of hemophiliacs in Alabama. One subcutaneous injection per week (or even every […]

Bleeding Disorders

March 2020 Quick Question

Look to the right for our March, 2020 Quick Question, “How does your facility measure extended half-life factor VIII concentrate therapy?” After you select your answer please add your comments by sending an email to [email protected].

Bleeding Disorders

Feb, 2020 Quick Question: Chronic Bleeding

Our February, 2020 Quick Question, which drew 114 answers, asks, “For chronic bleeds, poor wound healing with normal PT, PTT, FG and platelets, what assay should be next?” Answers: Factor VIII: 18% (21) Factor IX: 3% (3) Factor XI: 4% (5) Factor XIII: 75% (85) The question was meant to draw us to factor XIII […]

Bleeding Disorders

Chromogenic Factor VIII Assay

The Thrombosis and Hemostasis Summit of North America (THSNA) convenes in Chicago Thursday, April 23 to Saturday April 25. Fritsma Factor’s sponsor, Precision BioLogic Inc, Halifax, NS, and Affinity Biologicals, Inc,Toronto, ON will occupy booth 401. From 5:45 to 6:30 on Thursday, presenters will be located near their posters including the following posters developed by […]

Bleeding Disorders

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

Cheat Sheets from George

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