May 2024 QQ Summary: Platelet Transfusion Trigger

Our May 2024 Quick Question was a survey that asked, “Below what PLT count limit do you provide PLT concentrate?” our 25 participants answered as follows: <150,000/uL: 2 [8%] <50,000/uL: 3 [12%] <20,000/uL: 7 [28%] <10,000/uL: 13 [52%] <5,000/uL: 0 The correct answer is “it depends.” Current WHO platelet concentrate transfusion guidelines are available at […]

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Quick Question Archive

May 26 2024

george

Marstacimab Anti-TFPI Moab Submitted for FDA and EMA Approval

Pfizer has applied to the US FDA and the European Medicines Agency [EMA] for approval of their monoclonal antibody anti-tissue factor pathway inhibitor [TFPI] therapeutic, marsticimab, a competitor to Novo Nordisk’s concizumab, approved by Health Canada under the trademark Alhemo®, and awaiting FDA and EMA approval. The FDA anticipates an FDA ruling in the fourth […]

Bleeding Disorders

PBI Webinar: FVIII & FIX Testing of Emerging Therapies

I (Geo) recommend a May 8, 2024 Precision BioLogic webinar by Chief Scientific Officer Jon Geske, PhD and Marketing Director Ian Burns that compares one-stage clot-based and chromogenic assays when testing for the activity of extended half-life FVIII and FIX concentrates, FVIII mimetics such as emicizumab, RNAi‘s such as fitusiran, and the products of FVIII […]

Bleeding Disorders

May 2024: QQ Poll: Trigger Point for PLT Concentrate Therapy

Our May 2024 Quick Question asks, “Below what PLT count limit do you provide PLT concentrate?” Please show us your facility’s PLT count limit and add a comment below or using the Questions or Comments box.

Bleeding Disorders

April 2024 QQ Summary: MYH9 Mutation

Our April 2024 Quick Question, “What PLT production abnormality is an MYH9 gene mutation?” attracted 26 responses. Here’s the distribution: Thrombocytopenia with absent radii [TAR]: 4 [15%] Bernard-Soulier syndrome [BSS]: 2 [7%] Immune thrombocytopenia [ITP]: 1 [4%] Wiskott-Aldrich syndrome: 1 [4%] May-Hegglin disorder: 18 [70%] The production abnormalities are associated with mild to severe bleeding. […]

Bleeding Disorders

VWD Diagnosis and Monitoring Update

Dr. Annette Bowyer posted this open-access publication today, 3-3-24 on LinkedIn: Platton S, Baker P, Bowyer A, et al. Guideline for laboratory diagnosis and monitoring of von Willebrand disease: A joint guideline from the United Kingdom Haemophilia Centre Doctors’ Organisation and the British Society for Haematology. Br J Haematol. 2024 Mar 26. doi: 10.1111/bjh.19385. Epub […]

Bleeding Disorders

April 2024 QQ: MYH9 Mutation

Molecular diagnostic methods have defined scores of platelet disorders that by phenotype alone were categorized as production or functional disorders. Our April 2024 Quick Question is a quiz that “scratches the surface” by asking what disorder or syndrome is part of the MYH9 gene mutation family. For a look at molecular diagnostics practical applications, see […]

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Platelet Function Testing

Mar 29 2024

george

March 2024 Quick Question Summary: Factor Deficiency

Our March 2024 Quick Question was a quiz. The question was, “What factor deficiency causes bleeding but doesn’t prolong the PT or PTT?” Our 75 respondents answered as follows: FVIII: 7 [9%] FIX: 3 [4%] FXI: 3 [4%] FXII: 8 [11%] FXIII: 54 [72%] Factor VIII, IX, XI, and XII deficiencies prolong the PTT but […]

Bleeding Disorders

How to Measure Plasma Efanesoctocog Alfa [Altuviiio]

For those like me (Geo) who are just learning of it, efanesoctocog alfa (Altuviiio™), US FDA-approved in February of 2023 is Sanofi/Sodi’s extended half-life synthetic FVIII concentrate. Here is an edited description of Altuviiio’s structure and PK from the package insert. Altuviiio (efanesoctocog alfa, ehtl, recombinant AHF, Fc–VWF-XTEN fusion protein) replaces missing FVIII needed for […]

Bleeding Disorders

March 2024 Quick Question: Factor Deficiency

Our March 2024 Quick Question, a factor deficiency quiz asks “What factor deficiency causes bleeding but doesn’t prolong the PT or PTT?” Please select the one correct answer and make additional comments below.

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Bleeding Disorders

Bleeding Disorders

May 2024 QQ Summary: Platelet Transfusion Trigger

Marstacimab Anti-TFPI Moab Submitted for FDA and EMA Approval

PBI Webinar: FVIII & FIX Testing of Emerging Therapies

May 2024: QQ Poll: Trigger Point for PLT Concentrate Therapy

April 2024 QQ Summary: MYH9 Mutation

VWD Diagnosis and Monitoring Update

April 2024 QQ: MYH9 Mutation

March 2024 Quick Question Summary: Factor Deficiency

How to Measure Plasma Efanesoctocog Alfa [Altuviiio]

March 2024 Quick Question: Factor Deficiency

George Fritsma MS MLS

Cheat Sheets from George

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