Bleeding Disorders

ISTH Poster: FVIII Deficient Plasma with VWF

Yesterday, July 12, 2022, at the ISTH annual meeting in London, England, the research staff of Precision BioLogic Inc., Dartmouth, Nova Scotia, Canada presented the poster: Kesavan N, Rahman M, Sadeghi-Khomami A, Black KM, Wood A. Performance of FVIII deficient plasma with VWF in the activity measurement of FVIII replacement products in plasma samples using […]

Bleeding Disorders

ISTH Poster: Chromogenic FIX Activity Assay

Yesterday, July 12, 2022, at the ISTH annual meeting in London, England, the research staff of Precision BioLogic Inc., Dartmouth, Nova Scotia, Canada presented the poster: Quinton T, Fraser J, Black KM, Sadeghi-Khomami A. Performance of a chromogenic factor IX activity assay in the recovery of factor IX replacement therapies, Abstract PB1183. Their data illustrate […]

Bleeding Disorders

Low Titer Group O Whole Blood

Here is a thought-provoking article by Charna Albert from the June 2022 issue of CAP Today entitled, “Lining up for low titer O whole blood in trauma care.” Please comment about your use of whole blood or refrigerated platelet concentrate to manage trauma-induced coagulopathy.

Bleeding Disorders

July 2022 QQ: Reduced concentration RIPA test.

Our July 2022 Quick Question asks, “What von Willebrand disease [VWD] subtype is identified using the reduced concentration ristocetin-induced platelet aggregometry [RIPA] test?” Many of the VWD types and subtypes are currently identified using molecular diagnosis, however, the “legacy” phenotypic tests often provide a speedy and inexpensive shortcut. This may be one such case. Please […]

Bleeding Disorders

Emicizumab in VWD

The opening plenary session of the World Federation of Hemophilia featured von Willebrand disease expert Dr. Peter Lenting, who reported on “Novel Treatment Options in von Willebrand Disease.” He reported on a case study in which emicizumab was used to successfully treat a type 3 VWD patient with anti-VWF inhibitors. The case study presentation appears […]

Bleeding Disorders

ISTH Guidelines for Treatment of TTP

Reminder, in 2020, the International Society for Thrombosis and Hemostasis [ISTH} released their “ISTH Diagnosis Guidelines” and “ISTH TTP Treatment Guidelines.”Click here for access to the guidelines and their supporting material.”

Bleeding Disorders

Chromogenic Factor IX Assay

On May 9, 2022, Precision BioLogic, Inc. [PBI] announced the release and international approval for their chromogenic factor IX assay. Click here for PBI’s press release. The product addresses the key need for accuracy when monitoring extended half-life coagulation factor concentrate therapy.

Bleeding Disorders

January 2022 Quick Question: Case Study

We had 58 responses to our January 2022 Quick Question. The stem asked, “A patient experiences soft tissue bleeding and poor wound healing. The PT, PTT, and TT are normal. What follow-up profile do you recommend? Factors VIII, IX, & XI assays: 10% [6] PAI-1 & D-dimer assays: 0 Thrombosis risk profile: 2% [1] Platelet […]

Bleeding Disorders

Chromogenic Vs. Clot-based Gene Transfer FVIII Assays

This article in Blood illustrates the disparity between chromogenic and clot-based factor VIII assays when measuring factor VIII activity produced by hemophilic recipients of gene transfer factor VIII: Rosen S, Tiefenbacker S, Robinson M, et al. Activity of transgene-produced B-domain–deleted factor VIII in human plasma following AAV5 gene therapy. Blood 2020;136:2524–34. Thanks to Dean Willett, […]

Bleeding Disorders

Biomarin Factor VIII Gene Transfer Results

Click here to see Biomarin’s 1-9-22 announcement of their 134-participant factor VIII gene transfer trial, valoctocogene roxaparvovec. Thanks to Dean Willett, Precision BioLogic Inc. for alerting us to this encouraging development.

Bleeding Disorders

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

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