Discussion of Phase I Data on a Unique anti-VWF Thrombolytic

A summary by Dr. Wolfgang Miesbach: A potential landmark thrombolytic innovation presented at ASH 2025. Thrilled by the exciting Phase 1 data presentation by Marie Scully and co-authors on TGD001, a groundbreaking novel von Willebrand factor (VWF)-targeting thrombolytic: First-of-its-kind mechanism: TGD001 is an antibody-enzyme fusion protein—specifically, an anti-VWF antibody fragment fused to a urokinase catalytic domain. […]

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Arterial Thrombosis

Dec 12 2025

george

Platelet Function Preservation Following Cell Salvage

Thanks to colleague Dave McGlasson, MS, MLS for identifying this open-access original research study that describes the effects of intraoperative cell salvage on platelet function. Blum LV, Sertdere F, Iken S, et al. Preservation of platelet function after intraoperative cell salvage using the i-SEP same device in cardiac surgery. J Cardiothorac Vasc Anesth. 2025:S1053-0770(25)01058-4. doi: […]

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Platelet Function Testing

Dec 11 2025

george

Associations of FVIII & FIX Levels with CVD and CVD Mortality

Go to your medical library to access this provocative journal article: Harris K, Woodward M, Folsom AR, et al. Associations between plasma levels of coagulation factors VIII and IX and incident cardiovascular disease and mortality: systematic review and meta-analysis. J Thromb Haemost. 2025:S1538-7836(25)00598-7. doi: 10.1016/j.jtha.2025.09.008. PMID: 41038279. Abstract Background: Associations of plasma levels of coagulation […]

Arterial Thrombosis

Neutrophil Extracellular Traps

Neutrophil extracellular trap (NET) research has gained prominence beginning in perhaps 2010. I’ve attached an open-access review that illustrates NETs‘ functions and shows how NETs connect neutrophils with hemostasis. The article also documents how NETs participate in the process of thrombosis. Click to download Huang G, Wu H, Lin B, et al. Targeting neutrophil extracellular […]

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What is PITT?

Click below for an open-access article that classifies VITT and HIT as members of a platelet factor 4 (PF4) disorder, anti-PF4 mediated thrombocytopenia and thrombosis (PITT). Nicolson PLR, Montague SJ, Buka RJ, et al. Anti-PF4 mediated thrombocytopenia and thrombosis associated with acute cytomegalovirus infection displays both HIT-like and VITT-like characteristics. Br J Haematol. 2025. doi: […]

Arterial Thrombosis

History of TTP

Thanks to Dr. X. Long Zheng, Professor and Chair of Pathology and Laboratory Medicine, University of Kansas, for his LinkedIn reference to this 2017 open access thrombotic thrombocytopenic purpura history: Saha M, McDaniel JK, Zheng XL. Thrombotic thrombocytopenic purpura: pathogenesis, diagnosis and potential novel therapeutics. J Thromb Haemost. 2017 Oct;15(10):1889-1900. doi: 10.1111/jth.13764.

Arterial Thrombosis

VWF in Malignancy

In the Rutgers CLSC 5124 Advanced Hemostasis graduate course, a participant responded to the question, “What do both Dr. Favaloro and Dr. Henry indicate about the role of platelets in metastatic carcinoma?.” The question referred to our Coag Conversations with Dr. Emmanuel Favaloro, The Many Faces of VWF. and with Dr. Brandon Henry, What Have […]

Arterial Thrombosis

VWF in Cardiac Disorders

In the Rutgers CLSD 5124 Advanced Hemostasis graduate course, a participant responded to the question, “Show how VWF and platelets appear to be involved in cardiac insufficiency and atrial fibrillation.” The question referred to our Coag Conversation with Dr. Emmanuel Favaloro, The Many Faces of VWF. The response: VWF is a glycoprotein heavily engaged in […]

Arterial Thrombosis

Trauma-induced Coagulopathy Conversation Part 3

Part 3 of my Coag Conversation with Dr. Maureane Hoffman entitled Trauma-induced Coagulopathy; The Laboratory’s Role in Care, is now available from the BioMedica Diagnostics website.

Bleeding Disorders

FXII and Inflammation

This question was posted in the Rutgers graduate course, CLSC 5124 Advanced Hemostasis: Explain how FXII and FXI are activated by vascular assist devices and show their connection with inflammation. Here is an answer provided by one of the course participants: The contact pathway may be initiated by FXII binding to a negatively charged surface […]

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Arterial Thrombosis

Arterial Thrombosis

Discussion of Phase I Data on a Unique anti-VWF Thrombolytic

Platelet Function Preservation Following Cell Salvage

Associations of FVIII & FIX Levels with CVD and CVD Mortality

Neutrophil Extracellular Traps

What is PITT?

History of TTP

VWF in Malignancy

VWF in Cardiac Disorders

Trauma-induced Coagulopathy Conversation Part 3

FXII and Inflammation

George Fritsma MS MLS

Cheat Sheets from George

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