Antiplatelet Therapy

Meds that Contain Aspirin

Angela Phillips from St. Jude Children’s Research Hospital asks, “We are looking for a listing of medications that contain aspirin/salicylates to compile a more detailed list in our coagulation laboratory (mainly for normal donor testing for control samples, etc.). Do you have this information or can you give me a resource that does? I found […]

Antiplatelet Therapy

Antiplatelet Therapy and Platelet Function Testing

In the interest of self-promotion and the dissemination of current information, I’ve posted three review articles prepared for the ASCLS Clinical Laboratory Science journal Focus series. They are… Fritsma GA. Antiplatelet drugs and platelet function testing. Clin Lab Sci 2015;28:122–4. Fritsma GA. Platelet structure and function. Clin Lab Sci 2015;28: 125–31. Fritsma GA. Managing antiplatelet […]

Antiplatelet Therapy

Favorable Cangrelor Review

The FDA study section reported a favorable review for the antiplatelet drug cangrelor developed by The Medicines Company, New Jersey. Read the committee report here. Cangrelor now awaits full FDA approval.

Antiplatelet Therapy

NSAIDS Raise Bleeding Risk Post-MI

Heartwire reviews a Februay 24 JAMA report indicating that AMI patients on DAPT who use NSAIDs double their risk of bleeding and secondary cardiovascular events. Read about it in Medscape.

Anticoagulant Therapy

Does Acetaminophen Interfere with the VerifyNow Asprin Test?

From Thomas Gage, MD, Lahey Medical Center. Greetings, I have a patient with a VerifyNow Aspirin test showing some inhibition. The patient had exposure to clopidogrel and acetaminophen, but not aspirin. So now I’m trying to figure out if acetaminophen can interfere with this test, and I’m getting conflicting opinions. Because the VerifyNow Aspirin test […]

Antiplatelet Therapy

Platelet Function Testing in the OR

From Jim Turner: Hey Mr Fritsma! Great site and I really like the longer hair! I now work for TriMedX. I am one of their clinical engineers here in Birmingham at St Vincent’s Medical Center. I (and others) are having a problem with this platelet activity instrument called the VerifyNow. The heaters on these things […]

Antiplatelet Therapy

Aspirin Inhibition Test–Accumetrics

On December 30, Pat Doleski at Kaleida Health asked, We perform aspirin and P2Y12 (clopidogrel) testing using the Accumetrics at two different sites in our hospital system. Twice per year we perform an “inter-lab” on a patient sample to show comparability. We use the 10% CV listed in the insert to determine acceptability, which works […]

Antiplatelet Therapy

QQ Responses: Platelet Function

Here are the results of our November, 2014 Quick Question: What platelet function test do you use for platelet function disorders and/or for aspirin and clopidogrel efficacy? a. Siemens PFA-100: 35%, 24 votes b, Accumetrics VerifyNow: 25%, 17 votes c. Light transmittance aggregometry: 18%, 12 votes d. None: 10%, 7 votes e. Whole blood impedance […]

Antiplatelet Therapy

Genotyping for Clopidogrel may not Work

A September 4, 2013 release from the European Society of Cardiology congress held in Amsterdam describes data from the ARCTIC-GENE study illustrating that genotyping for metabolic polymorphisms provides no improvement in clopidogrel therapy outcomes. You can read more in this linked Heart.com article.

Antiplatelet Therapy

Omaha Presentation Handouts

George substituted for Dave McGlasson and presented, “Monitoring the New Antithrombotics: Whatever Happened to the PT and PTT?” on Wednesday, April 3, 10 AM; and “Antiplatelet Therapy, Do Aspirin and Plavix Work?” on Thursday, April 3, 2:30–2:30 PM at the Great Plains Regional Laboratory Expo in Omaha Nebraska. His presentation handouts, in PDF, appear on our Audio Modules page. Thanks […]

Anticoagulant Therapy

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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