Jul 21 2020

george

What is Osocimab?

The first phase 2 antithrombotic efficacy and safety results for the novel anti-activated coagulation factor XI [anti-XIa] monoclonal antibody are reported in Weitz JI, Bauersachs R, Becker B, et al. Effect of osocimab in preventing venous thromboembolism among patients undergoing knee arthroplasty; The FOXTROT randomized clinical trial JAMA. 2020;323:130–9. doi:10.1001/jama.2019.20687. This is an exciting new approach […]

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Anticoagulant Therapy

Jul 17 2020

george

Can Heparin Prevent Covid?

Thanks to George’s colleague Rodney Rohde, PhD, Texas State University, who posted this Contagion Live article by Grant M. Gallagher on LinkedIn entitled FDA-Approved Anticoagulant May Stop Coronavirus From Binding to Human Cells [click or tap]. This is a suprising and apparently authentic description of a non-antithrombotic Covid-preventative property of heparin, separate from heparin’s prophylactic […]

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Anticoagulant Therapy

Jul 7 2020

george

Covid and Hemostasis Riley Article

For a succinct summary of hemostasis mechanisms and management in the Covid-19 infection, see Riley P. Pandemic care: The need for hemostasis testing in critically ill COVID-19 patients. MLO 5-20-20, accessed 7-7-20. Also visit Stago’s Edvantage Virtual University for their recent program, Thromboembolism in COVID-19: Laboratory Considerations by Michael P Gulseth, Pharm. D., BCPS, FMSHP, […]

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Anticoagulant Therapy

Jul 1 2020

george

INR and HCT Case

I [Geo] received this question from a participant on June 29, 2020: If I am at 3 for my CoaguChek reading can my hematocrit be 45 or more?  Does INR affect hematocrit? I have secondary polycythemia, had an unprovoked DVT and PE and take warfarin. I tet therapeutic phlebotomies, but just question if I’m at […]

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Anticoagulant Therapy

Jun 29 2020

george

Familial Thrombosis Case

George received this question on June 28, 2020, and has secured permission to post here while withholding the correspondent’s identity. Hello, and thank you for the Fritsma Factor. Our family is of Eastern Europe parentage and we have a genetic clotting family history. Several occurences have shown up at age 28 after a preceeding event. […]

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Anticoagulant Therapy

Jun 9 2020

george

More on the DOAC Dipstick

Please refer to our May 6, 2020 entry, “Detecting DOACs in Urine,” regarding the DOAC Dipstick®. Dr. Favaloro has given permission to post his editorial here. Please click or tap Favaloro E, Lippi G. The pointy end of point of care testing for direct oral anticoagulants. Thromb Haemost 2020: 120: 11–13. This product shows great […]

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Anticoagulant Therapy

May 17 2020

george

More on Covid and LAC

Thanks to Dr. Ali Sadeghi-Khomami, Precision BioLogic Inc., for sending a current editorial in press, Aubignat M, Godefroy O. COVID-19 and ischemic stroke: Should we systematically look for lupus anticoagulant and antiphospholipid antibodies? Revue neurologique 2020, https://doi.org/10.1016/j.neurol.2020.05.001. Please refer to our May 6 entry on antiphospholipid syndrome and the comment from Dr. Ning Tang. The […]

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Anticoagulant Therapy

Apr 23 2020

george

Covid and Hemostasis

On April 22, the Washington Post published an informative and alarming article on the relationship between Covid infection and hemostatic abnormalities. Critical Covid cases involve sepsis and abnormal hemostasis, primarily venous thromboembolic disease. The most current and authoritative resources for VTE management are the American Society of Hematology Covid Q&A site, https://lnkd.in/eDeurb7, and the Anticoagulation […]

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Anticoagulant Therapy

Mar 26 2020

george

AC Clinics and Covid-19

The Anticoagulation Forum conducted a webinar on Wednesday, March 25 entitled Management of Warfarin Patients Who Have Difficulty Getting INR Testing During COVID-19 Pandemic. Click or tap the title to see the recorded presentation, which centers on Warfarin management. Here are a few takeaways from the webinar, please feel free to add your observations below. […]

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Anticoagulant Therapy

Mar 6 2020

george

Detecting DOACs in Urine

George has been in touch with long-time colleague and friend, Jeanine Walenga, PhD, Loyola University Medical Center. Dr. Walenga collaborates with Dr. Job Harenberg of DOASENSE® in development of the DOAC Dipstick®, a qualitative urine immersion strip that detects a DOAC within ten minutes. A pad for the thrombin inhibitor dabigatran and a pad for […]

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Anticoagulant Therapy