Anticoagulant Therapy

A Review of Current and Developing DOAC Reversal Agents

Check with your medical library for this comprehensive review of current and developing DOAC reversal agents: Gómez-Outes A, Suárez-Gea ML, Lecumberri R. When and how to use reversal agents for direct oral anticoagulants? Curr Cardiol Rep. 2023;25:371–80. doi: 10.1007/s11886-023-01858-x. PMID: 36976497. Abstract Purpose of review: Our objective is to describe currently available reversal agents for […]

Anticoagulant Therapy

Heparin Resistance in Pancreatitis

Click this open-access article to read about heparin resistance in an acute pancreatitis patient with a normal antithrombin level: Rongqin D, Zhexin B, Yuzhi L, et al. Heparin resistance in a patient with severe acute pancreatitis: a case report. Lab Med. 2025;56:570–6. doi: 10.1093/labmed/lmae126. PMID: 40237706; PMCID: PMC12417076. Here’s the abstract: Introduction: Severe acute pancreatitis […]

Anticoagulant Therapy

ESC: Extended Apixaban Rx

Click here for an ESC news release: Extended apixaban therapy lowers recurrent VTE in patients with provoked events and enduring risk factors, released 9-1-2025.

Anticoagulant Therapy

Post-Orthopedic Surgery Anticoagulation

Click here to receive the open-access review article, Sarkar MK, Laposata M. Is aspirin the best choice today for prophylaxis against venous thromboembolism after orthopedic surgery? Tex Ortho J 2017:3; 45–54 DOI: 10.18600/toj.030407. Sarkar and Laposata reviewed various agency guidelines for all AC therapy over the past several years and provided the current recommendations.

Anticoagulant Therapy

August 2025 QQ: Direct Oral Anticoagulants

Our August 2025 QQ is a poll that asked, “What AC does your provider prescribe for non-valvular AFIB?” Here are the choices made by our 18 responders: Apixaban (Eliquis) 10 (56%) Clopidogrel (Plavix) 0 Dabigatran (Pradaxa) 3 (16%) Rivaroxaban (Xarelto) 1 (6%) Warfarin (Coumadin) 4 (22%) This QQ arose from discussions with my (Geo) PCP […]

Anticoagulant Therapy

Charcoal Adsorbents Remove Anti-FXIa Interference

My (Geo) audio PowerPoint, Managing Direct Oral Anticoagulants, was posted in 2021. One of the final slides indicates experimental anticoagulant formulations designed to suppress FXI activation, aiming to reduce thrombotic risk without increasing the risk of bleeding. Click open-access article Buckley GT, Crowley MP, Harte JV. Interferences associated with the factor XIa inhibitors asundexian and […]

Anticoagulant Therapy

More On Anti-Xa DOAC Variability

Click our 7-23-25 entry, Anti-Xa DOAC Variability for an 8-21-25 reference from Dr. Emmanuel Favaloro.

Anticoagulant Therapy

August 2025 QQ: Anticoagulant Choice for AFIB

Our August 2025 Quick Question asks, “What AC does your provider prescribe for non-valvular AFIB?” I (Geo) asked my PCP this question at my annual wellness visit on July 29, 2025. Not a personal concern, just curious. Please provide your answer on the right and add your comments, which will appear in our end-of-month summary.

Quick Question Archive

Anti-Xa DOAC Assay Variability

Click here to read an open-access article describing the variability in assay methodology when monitoring apixaban and rivaroxaban: Baker RM, Selby R, Moffat KA, et al. Investigating interassay variability between direct oral anticoagulant calibrated anti-factor Xa assays: a substudy of the perioperative anticoagulation use for surgery evaluation (PAUSE) trial. Res Pract Thromb Haemost. 2025;9:102899. doi: 10.1016/j.rpth.2025.102899. […]

Anticoagulant Therapy

What is Abelacimab?

In 2020 we posted news about a new anticoagulant osocimab, an early and ongoing effort to develop a monoclonal antibody that neutralizes FXI and FXIa. Click here for a press release from Anthos Therapeutics (formerly Blackstone Life Sciences) describing results from the AZALEA-TIMI 71 study that was discontinued early due to an overwhelming reduction in […]

Anticoagulant Therapy

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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