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Anticoagulant Therapy

Nov 14 2025
george

Commentary: Laboratory Implications of Transitioning from DOACs to Heparin.

Click here for an 11-13-2025  open-access article, Arachchillage DJ, Vinayagam S, Parsons A, Karawitage N, Laffan M. Transitioning of patients from direct-acting oral anticoagulant to heparin: impact on laboratory testing. Semin Thromb Hemost. 2025. doi: 10.1055/a-2734-2293. PMID: 41232561. Abstract Direct oral anticoagulants (DOACs), including direct thrombin inhibitors (dabigatran) and direct factor Xa inhibitors (apixaban, rivaroxaban, […]
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Anticoagulant Therapy
Nov 14 2025
george

Coag Conversation About Alternative Methods to Monitor Anticoagulant Therapy Part 2: Anticoagulation for Antiphospholipid Syndrome

Join me (Geo) and guest speaker Dr. Nicole Zantek, MD, PhD, Medical Director of the Special Coagulation Laboratory and Professor, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, as we discuss the pathophysiology of antiphospholipid antibodies and alternative methods to monitor warfarin and DOAC anticoagulation in patients diagnosed with APS. Click Anticoagulation […]
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Anticoagulant Therapy
Oct 30 2025
george

Case Study: Measuring TAT Complex in LVAD Implantation

Check with your library for this article describing the TAT Assay in LVAD Implantation. Ling L, Liu C, Zhou J. Thrombin-antithrombin complex might be a promising parameter for monitoring anticoagulation in the early postoperative period after LVAD implantation. Lab Med. 2025 ;56:423–7. doi: 10.1093/labmed/lmae113. PMID: 40085520. Abstract Introduction: Appropriate bridging anticoagulation is critical in the […]
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Anticoagulant Therapy
Oct 27 2025
george

A Coag Conversation: Alternate Warfarin Monitoring When the Prothrombin Time is Unreliable – Part 1

Join me (Geo) and guest speaker Dr. Nicole Zantek, MD, PhD, Medical Director of the Special Coagulation Laboratory, Professor, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, who discusses the pathophysiology of antiphospholipid antibodies, and alternative methods to monitor warfarin and DOAC anticoagulation in patients diagnosed with antiphospholipid syndrome. This is the […]
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Anticoagulant Therapy
Oct 25 2025
george

International Symposium on Intensive Care and Emergency Medicine: Nebulizer Delivery of Unfractionated Heparin

Thanks to Dave McGlasson, MS, MLS, for the heads-up about this open-access review of the International Symposium on Intensive Care and Emergency Medicine (Click Here). Bateman RM, Sharpe MD, Jagger JE, et al. 36th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 15–18 March 2016. Crit Care. 20160;20(Suppl 2):94. doi: 10.1186/s13054-016-1208-6. Erratum in: […]
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Anticoagulant Therapy
Oct 21 2025
george

Algorithm for DOAC Dipstick Application

Click here for the open-access article: Harenberg J, Gosselin RC, Cuker A, et al. Algorithm for rapid exclusion of clinically relevant plasma levels of direct oral anticoagulants in patients using the DOAC dipstick: an expert consensus paper. Thromb Haemost. 2024;124:770–7. doi: 10.1055/a-2261-1811. PMID: 38316416. Abstract Background With the widespread use of direct oral anticoagulants (DOACs), there […]
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Anticoagulant Therapy
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George Fritsma MS MLS

George Fritsma is a medical laboratory scientist, educator, and author. George  is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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What VWD subtype Is caused by a VWF gain of function?