Sep 28 2020

george

In Vitro DOAC ID and Removal

We reported on the DOAC-Dipstick®, and four in vitro devices designed to remove interfering DOACs from specimens prepared for clot-based and chromogenic substrate assays in our 9-30-20 article [click], McGlasson DL, Fritsma GA. In vitro detection and removal of direct oral anticoagulants from patient plasma specimens. Annals of Blood 9-30-20; doi: 10.21037/aob-20-16. These devices are […]

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Sep 26 2020

george

Covid-Coag Conversation Video

Thanks to all who participated in our  September 15, 2020 webinar, “COVID-Associated Coagulopathy: A Conversation about the Controversies & Confusion” [click] featuring Dr. Andrew Goodwin, University of Vermont Medical Center. Click the title line if you would like to view the webinar again or if you did not have the opportunity to attend the live […]

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Sep 18 2020

george

Dilute Thrombin Time

From Deanna Miller, Children’s Hospital of Alabama. Do you have any good references for diluted thrombin and utilization of this test?  What dilution is best? 1:1 or 1:3? Hello, Deanna, and thank you for your question. We use the plasma-diluted thrombin time to measure the direct thrombin inhibitors [DTIs] dabigatran, argatroban, or bivalirudin. The assay […]

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Jul 21 2020

george

What is Osocimab?

The first phase 2 antithrombotic efficacy and safety results for the novel anti-activated coagulation factor XI [anti-XIa] monoclonal antibody are reported in Weitz JI, Bauersachs R, Becker B, et al. Effect of osocimab in preventing venous thromboembolism among patients undergoing knee arthroplasty; The FOXTROT randomized clinical trial JAMA. 2020;323:130–9. doi:10.1001/jama.2019.20687. This is an exciting new approach […]

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Anticoagulant Therapy

Jul 17 2020

george

Can Heparin Prevent Covid?

Thanks to George’s colleague Rodney Rohde, PhD, Texas State University, who posted this Contagion Live article by Grant M. Gallagher on LinkedIn entitled FDA-Approved Anticoagulant May Stop Coronavirus From Binding to Human Cells [click or tap]. This is a suprising and apparently authentic description of a non-antithrombotic Covid-preventative property of heparin, separate from heparin’s prophylactic […]

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Jul 7 2020

george

Covid and Hemostasis Riley Article

For a succinct summary of hemostasis mechanisms and management in the Covid-19 infection, see Riley P. Pandemic care: The need for hemostasis testing in critically ill COVID-19 patients. MLO 5-20-20, accessed 7-7-20. Also visit Stago’s Edvantage Virtual University for their recent program, Thromboembolism in COVID-19: Laboratory Considerations by Michael P Gulseth, Pharm. D., BCPS, FMSHP, […]

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Jul 1 2020

george

INR and HCT Case

I [Geo] received this question from a participant on June 29, 2020: If I am at 3 for my CoaguChek reading can my hematocrit be 45 or more?  Does INR affect hematocrit? I have secondary polycythemia, had an unprovoked DVT and PE and take warfarin. I tet therapeutic phlebotomies, but just question if I’m at […]

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Anticoagulant Therapy

Jun 29 2020

george

Familial Thrombosis Case

George received this question on June 28, 2020, and has secured permission to post here while withholding the correspondent’s identity. Hello, and thank you for the Fritsma Factor. Our family is of Eastern Europe parentage and we have a genetic clotting family history. Several occurences have shown up at age 28 after a preceeding event. […]

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Anticoagulant Therapy

Jun 9 2020

george

More on the DOAC Dipstick

Please refer to our May 6, 2020 entry, “Detecting DOACs in Urine,” regarding the DOAC Dipstick®. Dr. Favaloro has given permission to post his editorial here. Please click or tap Favaloro E, Lippi G. The pointy end of point of care testing for direct oral anticoagulants. Thromb Haemost 2020: 120: 11–13. This product shows great […]

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May 17 2020

george

More on Covid and LAC

Thanks to Dr. Ali Sadeghi-Khomami, Precision BioLogic Inc., for sending a current editorial in press, Aubignat M, Godefroy O. COVID-19 and ischemic stroke: Should we systematically look for lupus anticoagulant and antiphospholipid antibodies? Revue neurologique 2020, https://doi.org/10.1016/j.neurol.2020.05.001. Please refer to our May 6 entry on antiphospholipid syndrome and the comment from Dr. Ning Tang. The […]

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