High-sensitivity D-dimer?

A colleague has seen references to a “High-sensitivity” D-dimer assay. George answered he’s not heard of this, perhaps it is just a synonym for a standard D-dimer assay. If you have any experience with this, please respond to [email protected] or comment below.

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Fibrinolysis

Sep 27 2019

george

Effect of High HCT on D-dimer Results

From Heather DeVries, Indiana University Medical Center. I’m seeking some advice on how to handle D-dimers in patients with elevated hematocrits. I saw a post on this subject in Fritsma Factor back in 2013. CLSI H59-A says to follow H21-A5 in general, which of course says to correct the anticoagulant volume. IL’s package insert for […]

Fibrinolysis

New Statistics on Hemophilia Prevalence

Thanks to Elaine Benoit, Precision BioLogic Inc., for the heads-up on this newly released hemophilia study revealing a higher prevalence than previously reported. Also, the life expectancy disadvantage data are striking. Researchers from McMaster University, North Carolina State University, Aix-Marseille University, and the University of Sheffield joined efforts to respond to a call to action […]

Bleeding Disorders

A Link Between aHUS and TTP

Click or tap September 3, 2019 UAB News for an article featuring X. Long Zheng, MD, PhD, Robert B. Adams Professor of Pathology and Division Director of Laboratory Medicine at the University of Alabama at Birmingham. Using knockout mice, Dr. Zheng’s group has established a link between complement control protein H deficiency, a mechanism that […]

Bleeding Disorders

Discard Prior to Coagulation Specimen Collection

George, I would like to get your thoughts and references if possible about the “proper” amount of blood to discard before drawing samples for coagulation testing. In the current environment of minimizing blood waste and limiting volume of blood draws, we are reviewing our current policy. Our current SOP states to draw and discard 20 […]

Specimen Management

September, 2019 Quick Question

Please go to our September, 2019 Quick Question on the right, “A 25-YO experienced chronic soft tissue bleeding and poor wound healing. His PT, PTT, and PLT count were normal. What follow-up assay is indicated?” If you don’t see an answer you like, please add a comment. Thank you.

Bleeding Disorders

August, 2019 QQ: DOAC Bridging

Our August, 2019 Quick Question, suggested by frequent contributor, Dave McGlasson, demonstrated the variability in clinical antithrombotic therapy bridging policies when a patient requires a procedure. Here is the question and answers provided by 70 participants: A 60-YO man taking 20 mg/day rivaroxaban for AFIB needs a high bleeding risk surgery. His creatinine is 0.9 […]

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Anticoagulant Therapy

Aug 30 2019

george

Anticoagulation After Valve Replacement

According to an August 28, 2019 Medscape post, according to pooled PARTNER 2 results, early anticoagulation was independently associated with fewer strokes after surgical valve replacement (hazard ratio, 0.17; P = .006) but with more minor bleeding after transcatheter valve replacement (HR, 1.72; P = .01). Click or tap here for the Medscape post.

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Anticoagulant Therapy

Aug 30 2019

george

Using the PTT After Cardiac Catheterization

From Lori Leppert: I saw a previous post from April 9, 2014 regarding the use of the PTT result as a guide to pulling a sheath. Do you know of any references that we can refer to that indicate the PTT level in which it would be safe to pull the sheath? See the comment […]

Screening Assays

Zontivity (vorapaxar)

I’m curious about how many of our participants monitor vorapaxar (Zontivity®, New American Therapeutics, Inc) antiplatelet therapy. Vorapaxar is the only protease-activated receptor-1 (PAR-1) antagonist that reduces thrombotic cardiovascular events in patients with a history of myocardial infarction or peripheral arterial disease, FDA-approved in 2014. Vorapaxar is used alongside dual antiplatelet therapy (aspirin and clopidogrel; aspirin and ticagrelor) […]

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Antiplatelet Therapy

All Posts

High-sensitivity D-dimer?

Effect of High HCT on D-dimer Results

New Statistics on Hemophilia Prevalence

A Link Between aHUS and TTP

Discard Prior to Coagulation Specimen Collection

September, 2019 Quick Question

August, 2019 QQ: DOAC Bridging

Anticoagulation After Valve Replacement

Using the PTT After Cardiac Catheterization

Zontivity (vorapaxar)

George Fritsma MS MLS

Cheat Sheets from George

Questions or Comments?

Quick Question