All Posts

September, 2019 Quick Question

Please go to our September, 2019 Quick Question on the right, “A 25-YO experienced chronic soft tissue bleeding and poor wound healing. His PT, PTT, and PLT count were normal. What follow-up assay is indicated?” If you don’t see an answer you like, please add a comment. Thank you.

Bleeding Disorders

August, 2019 QQ: DOAC Bridging

Our August, 2019 Quick Question, suggested by frequent contributor, Dave McGlasson, demonstrated the variability in clinical antithrombotic therapy bridging policies when a patient requires a procedure. Here is the question and answers provided by 70 participants: A 60-YO man taking 20 mg/day rivaroxaban for AFIB needs a high bleeding risk surgery. His creatinine is 0.9 […]

Anticoagulant Therapy

Anticoagulation After Valve Replacement

According to an August 28, 2019 Medscape post, according to pooled PARTNER 2 results, early anticoagulation was independently associated with fewer strokes after surgical valve replacement (hazard ratio, 0.17; P = .006) but with more minor bleeding after transcatheter valve replacement (HR, 1.72; P = .01). Click or tap here for the Medscape post.

Anticoagulant Therapy

Using the PTT After Cardiac Catheterization

From Lori Leppert: I saw a previous post from April 9, 2014 regarding the use of the PTT result as a guide to pulling a sheath. Do you know of any references that we can refer to that indicate the PTT level in which it would be safe to pull the sheath? See the comment […]

Screening Assays

Zontivity (vorapaxar)

I’m curious about how many of our participants monitor vorapaxar (Zontivity®, New American Therapeutics, Inc) antiplatelet therapy. Vorapaxar is the only protease-activated receptor-1 (PAR-1) antagonist that reduces thrombotic cardiovascular events in patients with a history of myocardial infarction or peripheral arterial disease, FDA-approved in 2014. Vorapaxar is used alongside dual antiplatelet therapy (aspirin and clopidogrel; aspirin and ticagrelor) […]

Antiplatelet Therapy

Factor Inhibitors: The SIPPET Study

Here is a short free full text article describing the outcomes of the 2010–17 Survey of Inhibitors in Plasma-Product Exposed Toddlers (SIPPET) study. The study compares inhibitor incidence arising from rFVIII (recombinant) concentrate compared to pdFVIII (plasma-derived) concentrate. Further, in an important addition to hemophilia therapy protocol, SIPPET also compares inhibitor incidence in hemophilic F8 […]

Bleeding Disorders

Hemostasis Curriculum

For those of us who have teaching responsibilities, here is a JTH pre-pub that provides a comprehensive list of hemostasis topics: Moffat KA, Kiencke V, Blanco AN, McLintock C, Peyvandi F, et al., International Society on Thrombosis and Haemostasis core curriculum project: core competencies in laboratory thrombosis and hemostasis. J Thromb Haemost. 2019. doi: 10.1111/jth.14601. […]

Graduate Courses

George leads Michigan State University’s graduate online hemostasis course, BLD 835: Hemostasis, Thrombosis, and Resource Management beginning August 28, 2019. Please contact MSU’s Biomedical Laboratory Science program for enrollment and registration information. In addition, George will participate in Rutgers University’s online Advanced Hemostasis course led by Dr. Catherine Otto, Rutgers School of Health Professions. Contact […]

July 2019 CAP DOACs Article

The July, 2019 issue of CAP Today offers an article describing hemostasis testing for patients on DOACs by Dr. Dorothy M. Adcock, Chief Medical Officer and Senior Vice President, LabCorp. Tap or click here for “What is the Impact of Direct Oral Anticoagulants?”

Anticoagulant Therapy

August, 2019 Cheat Sheet

Tap or Click here for our August Cheat Sheet. If you are a Cheat Sheet subscriber, this month’s sheet will arrive in your mailbox later this week.

Load more

George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

Cheat Sheets from George

Quick Question